微小RNA在心脏重塑和心力衰竭中的新作用。
The emerging role of microRNAs in cardiac remodeling and heart failure.
作者信息
Divakaran Vijay, Mann Douglas L
机构信息
Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, and Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Tex., USA.
出版信息
Circ Res. 2008 Nov 7;103(10):1072-83. doi: 10.1161/CIRCRESAHA.108.183087.
Abstract
Recent studies have suggested a potentially important role for a family of tiny regulatory RNAs, known as microRNAs (miRNAs or miRs), in the control of diverse aspects of cardiac function in health and disease. Although the field of miRNA biology is relatively new, there is emerging evidence that miRNAs may play an important role in the pathogenesis of heart failure through their ability to regulate the expression levels of genes that govern the process of adaptive and maladaptive cardiac remodeling. Here, we review the biology of miRNAs in relation to their role in modulating various aspects of the process of cardiac remodeling, as well as discuss the potential application of miRNA biology to the field of heart failure.
摘要
最近的研究表明，一类被称为微小RNA（miRNA或miR）的微小调节RNA家族，在健康和疾病状态下心脏功能的多个方面的调控中可能发挥着潜在的重要作用。尽管miRNA生物学领域相对较新，但越来越多的证据表明，miRNA可能通过调节控制适应性和适应性不良心脏重塑过程的基因的表达水平，在心力衰竭的发病机制中发挥重要作用。在此，我们综述了miRNA的生物学特性及其在调节心脏重塑过程各个方面的作用，并讨论了miRNA生物学在心力衰竭领域的潜在应用。
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