Melonakos Emmanuel J, Santucci Richard A
School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Adv Urol. 2008;2008:173694. doi: 10.1155/2008/173694. Epub 2008 Oct 28.
A 63-year old man was referred to us after three rapid recurrences of low-grade urethral papillary transitional cell carcinoma of the bulbar urethra, after repeated primary excision. Cystoscopy confirmed 3-4 low-grade urethral transitional cell carcinomas, which were subsequently fulgurated. After urethral healing, a solution of Mitomycin C (40 mg/80 cc) was instilled into the urethra for fifteen minutes and held in place with a penile clamp. Urethral instillations were repeated weekly for six weeks. The patient is currently disease-free more than one year and three months posttreatment. This case highlights the successful treatment of urethral carcinoma with topical chemotherapy, which is usually reserved for the bladder, using a slight modification of standard technique.
一名63岁男性在球部尿道低度乳头状移行细胞癌经多次初次切除后三次快速复发，随后被转诊至我院。膀胱镜检查证实有3 - 4处低度尿道移行细胞癌，随后进行了电灼治疗。尿道愈合后，将丝裂霉素C溶液（40毫克/80毫升）注入尿道15分钟，并用阴茎夹固定。每周重复尿道灌注，持续六周。目前患者在治疗后已无疾病生存超过一年零三个月。该病例突出了通过局部化疗成功治疗尿道癌，这通常用于膀胱癌，对标准技术稍作修改即可应用于尿道癌治疗。
