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Focal urethral stricturing following intraurethral mitomycin-C gel and the use of a penile clamp.尿道内注射丝裂霉素 C 凝胶及使用阴茎夹后出现的局灶性尿道狭窄
Case Rep Urol. 2012;2012:864741. doi: 10.1155/2012/864741. Epub 2012 Jul 8.
2
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本文引用的文献

1
Instillation of mitomycin C after transurethral resection of bladder cancer impairs wound healing: an animal model.经尿道膀胱肿瘤切除术联合丝裂霉素 C 膀胱灌注会损害伤口愈合：动物模型研究。
Anticancer Res. 2011 Mar;31(3):929-32.
2
Treatment of low-grade bulbar transitional cell carcinoma with urethral instillation of mitomycin C.丝裂霉素C尿道灌注治疗低度球部移行细胞癌
Adv Urol. 2008;2008:173694. doi: 10.1155/2008/173694. Epub 2008 Oct 28.
3
Prospective study of transitional cell carcinoma in the prostatic urethra and prostate in the cystoprostatectomy specimen. Incidence, characteristics and preoperative detection.前列腺膀胱切除标本中前列腺尿道和前列腺移行细胞癌的前瞻性研究。发病率、特征及术前检测。
Scand J Urol Nephrol. 2007;41(4):290-6. doi: 10.1080/00365590601183576.
4
Superficial urothelial cancer in the prostatic urethra.前列腺尿道浅表性尿路上皮癌。
ScientificWorldJournal. 2006 Feb 28;6:2603-10. doi: 10.1100/tsw.2006.402.
5
Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy.丝裂霉素C对尿道内切开术后前尿道狭窄复发的影响。
Eur Urol. 2007 Apr;51(4):1089-92; discussion 1092. doi: 10.1016/j.eururo.2006.11.038. Epub 2006 Nov 27.
6
Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.尿道内注射丝裂霉素-C对实验性诱导尿道狭窄大鼠愈合和纤维化的影响。
Int J Urol. 2004 Dec;11(12):1122-6. doi: 10.1111/j.1442-2042.2004.00959.x.
7
Extensive urethral stricture after using mitomycin in local anaesthetic jelly for urethral tumours.在将丝裂霉素用于局部麻醉凝胶治疗尿道肿瘤后出现广泛尿道狭窄。
BJU Int. 1999 May;83(7):873-4. doi: 10.1046/j.1464-410x.1999.00111.x.
8
Management of the patient with bladder cancer. Urethral recurrence.膀胱癌患者的管理。尿道复发。
Urol Clin North Am. 1994 Nov;21(4):645-51.
9
Transitional cell carcinoma of the prostate.前列腺移行细胞癌
J Urol. 1969 Feb;101(2):206-7. doi: 10.1016/s0022-5347(17)62313-9.

尿道内注射丝裂霉素 C 凝胶及使用阴茎夹后出现的局灶性尿道狭窄

Focal urethral stricturing following intraurethral mitomycin-C gel and the use of a penile clamp.

作者信息

Stanford Richard F J, Thomas Stephen A

机构信息

Royal Derby Hospital, Derby Hospitals NHS Foundation Trust, Uttoxeter Road, Derby DE22 3NE, UK.

出版信息

Case Rep Urol. 2012;2012:864741. doi: 10.1155/2012/864741. Epub 2012 Jul 8.

DOI:10.1155/2012/864741
PMID:22830069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3399364/
Abstract

We present a case of a 51-year-old gentleman, previously diagnosed with high-grade superficial transitional cell carcinoma of the bladder and treated with intravesical mitomycin C and BCG, who developed serial recurrences in the prostatic urethra. This was resected and treated further with intraurethral mitomycin-C gel. He subsequently developed an almost impassable distal penile urethral stricture, corresponding to the site of penile clamp application which we hypothesise is secondary to a combination of the mitomycin-C gel and penile clamp pressure.

摘要

我们报告一例51岁男性患者，此前被诊断为膀胱高级别浅表性移行细胞癌，接受了膀胱内丝裂霉素C和卡介苗治疗，该患者前列腺尿道出现了一系列复发。对其进行了切除，并进一步采用尿道内丝裂霉素C凝胶治疗。随后，他出现了几乎无法通过的阴茎远端尿道狭窄，这与阴茎夹应用部位相对应，我们推测这是丝裂霉素C凝胶和阴茎夹压力共同作用的结果。