Weissman Amir, Lowenstein Lior, Tal Joseph, Ohel Gonen, Calderon Ilan, Lightman Abraham
Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel.
Eur J Appl Physiol. 2009 Feb;105(3):381-6. doi: 10.1007/s00421-008-0914-4. Epub 2008 Nov 7.
Estrogens are involved in the modulation of the cardiovascular system, yet their effects in young women remains largely unknown. Women who undergo ovulation induction treatments attain extremely high estrogen concentrations during a very short time period. The aim of the present study was to evaluate the effects of an acute increase in estrogens on the autonomic nervous system modulation of heart rate variability (HRV). A total of 27 women undergoing ovulation induction and 14 normally menstruating women were prospectively studied. HRV was assessed during nadir and peak estrogen using time domain and power spectral density analyses. A significant increase in high-frequency spectral power (243 +/- 77 vs. 188 +/- 73 ms(2)/Hz, P < 0.01) with a significant decrease in the ratio of low to high-frequency power was observed during estrogen peak in women undergoing induction of ovulation. The acute increase in estrogen in women undergoing ovulation induction was associated with vagal activation and altered sympathovagal balance.
雌激素参与心血管系统的调节，但其对年轻女性的影响在很大程度上仍不明确。接受促排卵治疗的女性在极短时间内会达到极高的雌激素浓度。本研究的目的是评估雌激素急性升高对心率变异性（HRV）自主神经系统调节的影响。前瞻性地研究了27名接受促排卵治疗的女性和14名正常月经周期的女性。在雌激素水平最低和最高时，使用时域和功率谱密度分析评估HRV。在接受促排卵治疗的女性中，雌激素峰值时观察到高频谱功率显著增加（243±77 vs. 188±73 ms²/Hz，P<0.01），低频与高频功率之比显著降低。促排卵女性雌激素的急性升高与迷走神经激活和交感-迷走神经平衡改变有关。
