Gupta Nidhi, Gupta Ritu, Bakhshi Sameer
Laboratory Oncology Unit, Dr B R Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Pediatr Blood Cancer. 2009 Mar;52(3):411-3. doi: 10.1002/pbc.21842.
We report a 2-month-old infant with Parvovirus B19 infection presenting as transient myeloproliferation resembling juvenile myelomonocytic leukemia (JMML). Patient history, physical examination, and laboratory findings were suggestive of JMML. On viral serology, raised IgM and IgG titers for Parvovirus B19 infection were found in the absence of giant proerythroblasts and viral inclusions in the erythroid precursors. Follow-up showing a decrease in viral titers suggested parvovirus infection as an etiological factor for the development of myeloproliferative features. This case highlights the importance of viral serology in work-up myeloproliferative disorders of infancy and childhood.
我们报告了一名2个月大的感染细小病毒B19的婴儿，其表现为类似青少年骨髓单核细胞白血病（JMML）的短暂性骨髓增殖。患者病史、体格检查和实验室检查结果提示为JMML。病毒血清学检查发现，细小病毒B19感染的IgM和IgG滴度升高，而红系前体细胞中不存在巨大原红细胞和病毒包涵体。随访显示病毒滴度降低，提示细小病毒感染是骨髓增殖特征发展的一个病因。该病例突出了病毒血清学在婴幼儿和儿童骨髓增殖性疾病检查中的重要性。
