Goodall C M, Kennedy T H
Cancer Lett. 1976 May;1(5):295-8. doi: 10.1016/s0304-3835(75)97975-6.
Lifetime tests were done in NZR inbred rats of dimethylnitramine (DMNO) by addition to the drinking water (average dose 1.83 g/kg body weight) and in NZO mice by repeated subcutaneous injection from birth to 7 months of age followed by administration in drinking water (total average dose 4.72 g/kg body weight). Rats developed hepatocellular carcinomas (85%), some of which metastasized. Mice developed hepatocellular carcinomas (81%) and renal adenocarcinomas (48%). Statistically significant increases of other tumor types also occurred in mice. The main targets for DMNO carcinogenesis appeared to be the liver cell epithelium and, at higher dose rates, renal tubular epithelium.
通过在饮水中添加二甲基硝胺（DMNO）（平均剂量1.83克/千克体重），对新西兰大鼠（NZR）进行终生试验；对新西兰小鼠（NZO）从出生到7个月龄进行反复皮下注射，之后在饮水中给药（总平均剂量4.72克/千克体重），进行终生试验。大鼠发生肝细胞癌（85%），其中一些发生转移。小鼠发生肝细胞癌（81%）和肾腺癌（48%）。小鼠中其他肿瘤类型在统计学上也有显著增加。DMNO致癌的主要靶器官似乎是肝细胞上皮，在较高剂量率下，还有肾小管上皮。
