Kao Tzu-Jen, Saulnier Gary J, Isaacson David, Szabo Tomas L, Newell Jonathan C
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
IEEE Trans Biomed Eng. 2008 Nov;55(11):2601-7. doi: 10.1109/TBME.2008.2001287.
Phantoms are frequently used in medical imaging systems to test hardware, reconstruction algorithms, and the interpretation of data. This report describes and characterizes the use of powdered graphite as a means of adding a significant reactive component or permittivity to useful phantom media for electrical impedance imaging. The phantom materials produced have usable complex admittivity at the electrical impedance tomography (EIT) frequencies from a few kilohertz to 1 MHz, as measured by our EIT system (ACT4) and by a commercial bioimpedance analyzer (BIS 4000, Xitron). We have also studied a commercial ultrasound coupling gel, which is highly electrically conductive and semisolid but that permits objects to move within it. The mixture of agar-graphite and gel-graphite, increases in permittivity and conductivity are proportional to the graphite concentration. We also report the use of a porous polymer membrane to simulate skin. A thin layer of this membrane increased resistance and the characteristic frequency of the phantoms, providing a promising candidate to simulate the effect of skin and the layered structure of a breast or other anatomical structure. The graphite also provides a realistic level of "speckle" in ultrasound images of the phantom, which may be useful in developing dual-mode imaging systems with ultrasound and the EIT.
体模在医学成像系统中经常被用于测试硬件、重建算法以及数据解读。本报告描述并表征了使用粉末状石墨作为一种向用于电阻抗成像的有用体模介质中添加显著反应成分或介电常数的方法。通过我们的电阻抗断层成像(EIT)系统(ACT4)以及商用生物阻抗分析仪(BIS 4000,Xitron)测量,所制备的体模材料在从几kHz到1MHz的电阻抗断层扫描(EIT)频率下具有可用的复导纳。我们还研究了一种商用超声耦合凝胶,它具有高导电性且为半固体,但允许物体在其中移动。琼脂 - 石墨和凝胶 - 石墨的混合物,其介电常数和电导率的增加与石墨浓度成正比。我们还报告了使用多孔聚合物膜来模拟皮肤。该膜的薄层增加了体模的电阻和特征频率,为模拟皮肤以及乳房或其他解剖结构的分层结构的效果提供了一个有前景的候选材料。石墨还在体模的超声图像中提供了逼真程度的“斑点”,这在开发具有超声和EIT的双模式成像系统中可能是有用的。