Gosselin R D, Dansereau M A, Pohl M, Kitabgi P, Beaudet N, Sarret P, Mélik Parsadaniantz S
Unités mixtes 732 & 713 INSERM, Université P et M Curie-Paris 06, Hôpital Saint-Antoine et Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Curr Med Chem. 2008;15(27):2866-75. doi: 10.2174/092986708786242822.
Physical insults including but not limited to nerve damage, inflammation, visceral pathologies and cancer generate long lasting pain commonly referred as chronic pain. Recently, members of the chemokine family and their receptors emerged as key modulators in nociceptive influx transmission in neuropathic and inflammatory chronic pain models. To this day, rodents defective in specific chemokine receptors have provided evidence of the implication of chemokine in pain sensitivity. In addition, up-regulation of chemokines and their receptors at multiple levels in the central nervous (CNS) and peripheral (PNS) systems is associated in the development of chronic pain. Indeed, we point out the fact that chemokines are synthesized and released by both neuronal and non-neuronal cells and act as neuromodulators. Even if their functional roles in the CNS remain largely unknown, chemokines participate in the glial activation and modulation of neuronal excitability as well as neurotransmitter release. This review focuses on three chemokines (i.e. CCL2, CXCL12, CX3CL1) recently identified as important mediators of the initiation and maintenance of pain hypersensitivity, thus broadening the panel of new strategies for the management of chronic pain.
包括但不限于神经损伤、炎症、内脏病变和癌症在内的物理性损伤会产生持久的疼痛，通常被称为慢性疼痛。最近，趋化因子家族成员及其受体在神经性和炎症性慢性疼痛模型的伤害性传入传递中成为关键调节因子。时至今日，特定趋化因子受体存在缺陷的啮齿动物已为趋化因子与疼痛敏感性之间的关联提供了证据。此外，中枢神经系统（CNS）和外周神经系统（PNS）多个层面上趋化因子及其受体的上调与慢性疼痛的发展有关。事实上，我们指出趋化因子由神经元细胞和非神经元细胞合成并释放，并作为神经调节剂发挥作用这一事实。即使它们在中枢神经系统中的功能作用在很大程度上仍不为人所知，但趋化因子参与了神经胶质细胞的激活、神经元兴奋性的调节以及神经递质的释放。本综述聚焦于最近被确定为疼痛超敏反应起始和维持的重要介质的三种趋化因子（即CCL2、CXCL12、CX3CL1），从而拓宽了慢性疼痛管理的新策略范围。
