Sircar Ratna, Basak Ashim, Sircar Debashish
Departments of Psychiatry and Behavioral Sciences, Neurology,and Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Ann N Y Acad Sci. 2008 Oct;1139:386-9. doi: 10.1196/annals.1432.044.
gamma-hydroxybutyric acid (GHB), a "club drug," is abused for its euphoric, sedative, and anabolic effects. GHB use and abuse is most prevalent among adolescents and young adults. Most GHB users report amnesia. In the present study, we tested the hypothesis that GHB treatment in female adolescent rats causes deficits in spatial learning and memory. Adolescent female rats were treated daily with GHB (100 mg/kg) for 5 consecutive days. Control rats received isovolumetric saline. Experimental and control rats were tested in the hidden platform task (reference memory) of the Morris water maze. GHB-treated adolescent female rats had significantly longer latencies than saline-treated controls, and in the probe trial drug-treated rats spent less time in the quadrant where the platform was present prior to its removal than did control adolescent rats. Together, these data indicate that GHB exposure in adolescent female rats has a negative impact on spatial learning and memory.
γ-羟基丁酸（GHB），一种“俱乐部毒品”，因其带来欣快感、镇静作用和合成代谢作用而被滥用。GHB的使用和滥用在青少年和年轻人中最为普遍。大多数GHB使用者报告有失忆现象。在本研究中，我们检验了以下假设：对青春期雌性大鼠进行GHB治疗会导致空间学习和记忆缺陷。青春期雌性大鼠连续5天每天接受GHB（100毫克/千克）治疗。对照大鼠接受等体积的生理盐水。实验大鼠和对照大鼠在莫里斯水迷宫的隐藏平台任务（参考记忆）中接受测试。接受GHB治疗的青春期雌性大鼠的潜伏期明显长于接受生理盐水治疗的对照组，并且在探针试验中，接受药物治疗的大鼠在平台移除前所在象限停留的时间比对照青春期大鼠少。总之，这些数据表明，青春期雌性大鼠接触GHB对空间学习和记忆有负面影响。
