α-S-半乳糖神经酰胺：用于刺激不变自然杀伤T细胞的合成与评估
Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation.
作者信息
Blauvelt Marisa L, Khalili Maryam, Jaung Weonjoo, Paulsen Janet, Anderson Amy C, Brian Wilson S, Howell Amy R
机构信息
Department of Chemistry, University of Connecticut, 55 N. Eagleville Road, Storrs, CT 06269-3060, USA.
出版信息
Bioorg Med Chem Lett. 2008 Dec 15;18(24):6374-6. doi: 10.1016/j.bmcl.2008.10.086. Epub 2008 Nov 1.
Abstract
The synthesis and evaluation for iNKT stimulation of alpha-S-galactosylceramide is reported. Prepared by alkylation of a galactosylthiol, this analog of the potent immunostimulatory agent, KRN7000, did not stimulate iNKT cells either in vitro or in vivo.
摘要
报道了α-S-半乳糖神经酰胺用于刺激不变自然杀伤T细胞（iNKT）的合成及评估。该强效免疫刺激剂KRN7000的类似物通过半乳糖硫醇的烷基化制备，在体外或体内均未刺激iNKT细胞。
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