2''-脱氧-β-半乳糖神经酰胺的合成

Thakur Meena S, Khurana Archana, Kronenberg Mitchell, Howell Amy R

Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA.

La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

Molecules. 2014 Jul 10;19(7):10090-102. doi: 10.3390/molecules190710090.

Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2"-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.

对CD1d/糖基神经酰胺/iNKT细胞以及CD1d/硫苷脂/硫苷脂反应性II型NKT细胞三元复合物的结构研究表明，糖脂上的极性部分如何与抗原呈递蛋白（CD1d）和T细胞受体相互作用。然而，仅这些结构并不能揭示这些相互作用的相对重要性。本研究聚焦于合成此前未知的2"-脱氧-β-半乳糖基神经酰胺2。还对这种糖脂刺激iNKT细胞和硫苷脂反应性II型NKT细胞的能力进行了评估。