Perlmutter N S, Wilson R A, Angello D A, Palac R T, Lin J, Brown B G
Div. of Cardiology, Oregon Health Sciences Univ., Portland 97201-3098.
J Nucl Med. 1991 Feb;32(2):193-200.
To investigate whether i.v. infusion of ribose, an adenine nucleotide precursor, postischemia facilitates thallium-201 (201Tl) redistribution and improves identification of ischemic myocardium in patients with coronary artery disease (CAD), 17 patients underwent two exercise 201Tl stress tests, performed 1-2 wk apart. After immediate postexercise planar imaging, patients received either i.v. ribose (3.3 mg/kg/min x 30 min) or saline as a control. Additional imaging was performed 1 and 4 hr postexercise. Reversible defects were identified by count-profile analysis. Significantly more (nearly twice as many) reversible 201Tl defects were identified on the post-ribose images compared to the post-saline (control) images at both 1 and 4 hr postexercise (p less than 0.001). Quantitative analyses of the coronary arteriogram was available in 13 patients and confirmed that the additional reversible defects were in myocardial regions supplied by stenosed arteries. We conclude that ribose appears to facilitate 201Tl redistribution in patients with CAD and enhances identification of ischemic myocardium.
为研究在缺血后静脉输注腺嘌呤核苷酸前体核糖是否能促进冠心病（CAD）患者的铊-201（²⁰¹Tl）再分布并改善缺血心肌的识别，17例患者接受了两次运动²⁰¹Tl负荷试验，试验间隔1 - 2周。运动后即刻进行平面显像后，患者分别接受静脉输注核糖（3.3 mg/kg/min×30分钟）或生理盐水作为对照。运动后1小时和4小时进行额外显像。通过计数轮廓分析识别可逆性缺损。运动后1小时和4小时，与生理盐水（对照）显像相比，核糖显像上识别出的可逆性²⁰¹Tl缺损显著更多（几乎多一倍）（p＜0.001）。13例患者有冠状动脉造影的定量分析结果，证实额外的可逆性缺损位于狭窄动脉供血的心肌区域。我们得出结论，核糖似乎能促进CAD患者的²⁰¹Tl再分布并增强缺血心肌的识别。
