Alzoubi Karem H, Ismail Zuhair Bani, Al-Essa Mohamed K, Alshogran Osama Y, Abutayeh Reem F, Abu-Baker Nareman
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Clin Pharmacol. 2018 Jun 12;10:73-78. doi: 10.2147/CPAA.S167150. eCollection 2018.
This study explored D-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits.
D-ribose was administered once as 420 mg/kg (N=4) or 840 mg/kg (N=6) dose intravenously, or as an oral dose of 420 mg/kg (N=3) or 840 mg/kg (N=3). Serum was obtained at various time points, up to 210 minutes after administration. Urine was also collected after IV administration. Pharmacokinetic parameters were determined from drug concentration-time data using Kinetica software.
The findings showed that D-ribose follows a dose-dependent kinetic profile. With doubling the IV dose, AUC was significantly increased by threefold, while the clearance was decreased by 44%. The half-life was 1.7-fold longer at the higher dose. Similar nonsignificant trends were also observed at oral administration. D-ribose was rapidly absorbed (T=36-44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18-37.5%) recovered from urine.
Collectively, D-ribose showed a dose-dependent kinetic profile, where parameters change according to dosing levels. D-ribose clearance seems to follow first-order kinetics at low dose. Thereafter, elimination systems are saturated, and elimination continues in a fast manner. Urine recovery was partial, which could be attributed to the several metabolic pathways that pentose can undergo.
本研究探讨了健康家兔静脉注射（IV）和口服D-核糖后的药代动力学。
以420mg/kg（N = 4）或840mg/kg（N = 6）的剂量静脉注射D-核糖一次，或以420mg/kg（N = 3）或840mg/kg（N = 3）的剂量口服。在给药后长达210分钟的不同时间点采集血清。静脉注射后也收集尿液。使用Kinetica软件根据药物浓度-时间数据确定药代动力学参数。
研究结果表明，D-核糖呈现剂量依赖性动力学特征。静脉注射剂量加倍时，曲线下面积（AUC）显著增加三倍，而清除率降低44%。高剂量时半衰期延长1.7倍。口服给药时也观察到类似的非显著趋势。D-核糖吸收迅速（T = 36 - 44分钟），并在血浆中迅速消失（<140分钟内）。此外，D-核糖可从尿液中部分回收（18 - 37.5%）。
总体而言，D-核糖呈现剂量依赖性动力学特征，其参数随给药水平而变化。低剂量时D-核糖清除似乎遵循一级动力学。此后，消除系统饱和，消除以快速方式持续进行。尿液回收是部分性的，这可能归因于戊糖可经历的多种代谢途径。
