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通过细胞磁共振成像检测和定量磁性标记的细胞。

Detection and quantification of magnetically labeled cells by cellular MRI.

作者信息

Liu Wei, Frank Joseph A

机构信息

Philips Research North America, Briarcliff Manor, NY 10510, USA.

出版信息

Eur J Radiol. 2009 May;70(2):258-64. doi: 10.1016/j.ejrad.2008.09.021. Epub 2008 Nov 7.

Abstract

Labeling cells with superparamagnetic iron oxide (SPIO) nanoparticles, paramagnetic contrast agent (gadolinium) or perfluorocarbons allows for the possibility of tracking single or clusters of labeled cells within target tissues following either direct implantation or intravenous injection. This review summarizes the practical issues regarding detection and quantification of magnetically labeled cells with various MRI contrast agents with a focus on SPIO nanoparticles.

摘要

用超顺磁性氧化铁(SPIO)纳米颗粒、顺磁性造影剂(钆)或全氟碳化合物标记细胞,使得在直接植入或静脉注射后能够追踪靶组织内单个或成群的标记细胞。本综述总结了有关使用各种MRI造影剂检测和定量磁性标记细胞的实际问题,重点是SPIO纳米颗粒。

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