de Luis Daniel A, Aller Rocio, Izaola Olatz, Gonzalez-Sagrado Manuel, Conde Rosa
Institute of Endocrinology and Nutrition, School of Medicine and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
Arch Med Res. 2008 Nov;39(8):791-5. doi: 10.1016/j.arcmed.2008.09.004.
Genetic background of presurgical morbidly obese patients may have an influence on follow-up and outcome. A genetic variant is the Trp64Arg missense mutation in the beta3-adrenoreceptor (beta3-AR) gene.
We investigated the influence of the Trp64Arg polymorphism in the beta3-AR gene on adipocytokines and cardiovascular risk factors in presurgical morbidly obese patients. A population of 56 presurgical morbidly obese patients was analyzed. Indirect calorimetry, tetrapolar bioimpedance, blood pressure, serial assessment of nutritional intake with a 3-day written food record, and biochemical parameters were measured. Genotype of beta3-AR gene polymorphism (Trp64Arg) was studied.
Mean age was 50.2+/-4.2 years and mean BMI was 46.8+/-4.7 with 11 males (19.6%) and 45 females (80.4%). There were 45 patients (9 males/36 females) (80.4%) who had the genotype Trp64/Trp64 (wild-type group) with an average age of 53.2+/-14 years, and there were 11 patients (2 males/9 females) Trp64/Arg64 (19.6%) (mutant group) with an average age of 47.7+/-15.6 years. In the mutant group, body mass index (BMI), weight, fat mass, waist circumference, total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, fibrinogen, and C-reactive protein (CRP) were higher than wild-type group. Adipocytokine levels were similar in both groups.
In the mutant group of beta3-AR gene (Trp64/Arg64), presurgical morbidly obese patients have a poorer inflammatory profile, lipid profile and fat distribution than wild-type group. Perhaps a future presurgical evaluation of morbidly obese patients would be necessary for genetic profiling.
术前病态肥胖患者的遗传背景可能会对随访及预后产生影响。一种基因变异是β3-肾上腺素能受体（β3-AR）基因中的色氨酸64精氨酸错义突变。
我们研究了β3-AR基因中色氨酸64精氨酸多态性对术前病态肥胖患者脂肪细胞因子及心血管危险因素的影响。分析了56例术前病态肥胖患者。测量了间接测热法、四极生物阻抗、血压、通过3天书面饮食记录进行的营养摄入连续评估以及生化参数。研究了β3-AR基因多态性（色氨酸64精氨酸）的基因型。
平均年龄为50.2±4.2岁，平均体重指数为46.8±4.7，其中男性11例（19.6%），女性45例（80.4%）。有45例患者（9例男性/36例女性）（80.4%）具有Trp64/Trp64基因型（野生型组），平均年龄为53.2±14岁，有11例患者（2例男性/9例女性）为Trp64/Arg64（19.6%）（突变组），平均年龄为47.7±15.6岁。在突变组中，体重指数（BMI）、体重、脂肪量、腰围、总胆固醇、低密度脂蛋白（LDL）胆固醇、甘油三酯、纤维蛋白原和C反应蛋白（CRP）均高于野生型组。两组的脂肪细胞因子水平相似。
在β3-AR基因的突变组（Trp64/Arg64）中，术前病态肥胖患者的炎症指标、血脂谱和脂肪分布比野生型组更差。或许未来对病态肥胖患者进行术前基因谱评估是必要的。
