爱泼斯坦-巴尔病毒相关恶性肿瘤的免疫逃逸
Immune escape by Epstein-Barr virus associated malignancies.
作者信息
Münz Christian, Moormann Ann
机构信息
Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland.
出版信息
Semin Cancer Biol. 2008 Dec;18(6):381-7. doi: 10.1016/j.semcancer.2008.10.002. Epub 2008 Oct 19.
Abstract
Persistent Epstein-Barr virus (EBV) infection remains asymptomatic in the majority of virus carriers, despite the potent growth transforming potential of this virus. The increased frequency of EBV associated B cell lymphomas in immune compromised individuals suggests that tumor-free chronic infection with this virus is in part due to immune control. Here we discuss the evidence that loss of selective components of EBV specific immunity might contribute to EBV associated malignancies, like nasopharyngeal carcinoma, Burkitt's and Hodgkin's lymphoma, in otherwise immune competent patients. Furthermore, we discuss how current vaccine approaches against EBV might be able to target these selective deficiencies.
摘要
尽管爱泼斯坦-巴尔病毒（EBV）具有强大的生长转化潜力，但在大多数病毒携带者中，持续性EBV感染仍无症状。免疫功能低下个体中EBV相关B细胞淋巴瘤的发病率增加，这表明该病毒的无瘤慢性感染部分归因于免疫控制。在此，我们讨论相关证据，即EBV特异性免疫的某些选择性成分缺失可能导致原本免疫功能正常的患者发生EBV相关恶性肿瘤，如鼻咽癌、伯基特淋巴瘤和霍奇金淋巴瘤。此外，我们还讨论了当前针对EBV的疫苗策略如何能够针对这些选择性缺陷。
相似文献
1
Immune escape by Epstein-Barr virus associated malignancies.爱泼斯坦-巴尔病毒相关恶性肿瘤的免疫逃逸
Semin Cancer Biol. 2008 Dec;18(6):381-7. doi: 10.1016/j.semcancer.2008.10.002. Epub 2008 Oct 19.
2
CD4+ T cell responses in the immune control against latent infection by Epstein-Barr virus.CD4 + T细胞应答在针对爱泼斯坦 - 巴尔病毒潜伏感染的免疫控制中的作用
Curr Mol Med. 2003 Jun;3(4):341-7. doi: 10.2174/1566524033479771.
3
The immune response to Epstein-Barr virus.对爱泼斯坦-巴尔病毒的免疫反应。
Microbes Infect. 2004 Aug;6(10):937-45. doi: 10.1016/j.micinf.2004.04.014.
4
Epstein Barr virus - a tumor virus that needs cytotoxic lymphocytes to persist asymptomatically.爱泼斯坦-巴尔病毒——一种肿瘤病毒，它需要细胞毒性淋巴细胞才能无症状持续存在。
Curr Opin Virol. 2016 Oct;20:34-39. doi: 10.1016/j.coviro.2016.08.010. Epub 2016 Sep 1.
5
Treatment options for post-transplant lymphoproliferative disorder and other Epstein-Barr virus-associated malignancies.移植后淋巴细胞增生性疾病及其他与爱泼斯坦-巴尔病毒相关的恶性肿瘤的治疗选择。
Tissue Antigens. 2004 Apr;63(4):285-92. doi: 10.1111/j.0001-2815.2004.00227.x.
6
Early impairment of CD8+ T cells immune response against Epstein-Barr virus (EBV) antigens associated with high level of circulating mononuclear EBV DNA load in HIV infection.在HIV感染中，CD8 + T细胞针对爱泼斯坦-巴尔病毒（EBV）抗原的免疫反应早期受损，这与循环单核细胞EBV DNA载量高水平相关。
J Clin Immunol. 2004 Mar;24(2):125-34. doi: 10.1023/B:JOCI.0000019777.75784.6f.
7
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.爱泼斯坦-巴尔病毒通过多种基因产物的协同作用逃避CD8(+)和CD4(+) T细胞免疫。
Semin Cancer Biol. 2008 Dec;18(6):397-408. doi: 10.1016/j.semcancer.2008.10.008. Epub 2008 Oct 25.
8
The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.病毒特异性 CD4+ T 细胞在控制 Epstein-Barr 病毒感染中的作用。
Eur J Cell Biol. 2012 Jan;91(1):31-5. doi: 10.1016/j.ejcb.2011.01.007. Epub 2011 Apr 1.
9
Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?共济失调毛细血管扩张症相关的 EBV 相关淋巴组织增生性疾病：ATM 是否调节 EBV 生命周期？
Front Immunol. 2019 Jan 4;9:3060. doi: 10.3389/fimmu.2018.03060. eCollection 2018.
10
The human T cell immune response to Epstein-Barr virus.人类对爱泼斯坦-巴尔病毒的T细胞免疫反应。
Int J Dev Biol. 2005;49(2-3):285-92. doi: 10.1387/ijdb.041947el.
引用本文的文献
1
IRF4 Mediates Immune Evasion to Facilitate EBV Transformation.IRF4介导免疫逃逸以促进EB病毒转化。
Viruses. 2025 Jun 24;17(7):885. doi: 10.3390/v17070885.
2
Management of Patients with IBD and History of Cancer.炎症性肠病合并癌症病史患者的管理
Cancers (Basel). 2025 Mar 21;17(7):1057. doi: 10.3390/cancers17071057.
3
Immune-Mediated Inflammatory Diseases and Cancer - a dangerous liaison.免疫介导的炎症性疾病与癌症——一种危险的关联。
Front Immunol. 2024 Sep 18;15:1436581. doi: 10.3389/fimmu.2024.1436581. eCollection 2024.
4
Epstein-Barr Viruses: Their Immune Evasion Strategies and Implications for Autoimmune Diseases.爱泼斯坦-巴尔病毒：它们的免疫逃逸策略及其对自身免疫性疾病的影响。
Int J Mol Sci. 2024 Jul 26;25(15):8160. doi: 10.3390/ijms25158160.
5
Worldwide Prevalence of Epstein-Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis.全球伯基特淋巴瘤患者中爱泼斯坦-巴尔病毒的流行率：一项系统评价和荟萃分析。
Diagnostics (Basel). 2023 Jun 15;13(12):2068. doi: 10.3390/diagnostics13122068.
6
Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts.含 Epstein-Barr 病毒产物的外泌体通过激活成纤维细胞中的 YAP1/FAPα 信号通路促进纤维化和鼻咽癌的进展。
J Exp Clin Cancer Res. 2022 Aug 20;41(1):254. doi: 10.1186/s13046-022-02456-5.
7
EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis.EBV 感染及其在鼻咽癌发生中的代谢重编程调控。
Front Cell Infect Microbiol. 2022 Jul 1;12:935205. doi: 10.3389/fcimb.2022.935205. eCollection 2022.
8
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22.EBV+ 肿瘤利用肿瘤细胞内在和外在机制产生招募调节性 T 细胞的趋化因子 CCL17 和 CCL22。
PLoS Pathog. 2022 Jan 13;18(1):e1010200. doi: 10.1371/journal.ppat.1010200. eCollection 2022 Jan.
9
Regulation of the Immune Checkpoint Indoleamine 2,3-Dioxygenase Expression by Epstein-Barr Virus.EBV 对免疫检查点吲哚胺 2,3-双加氧酶表达的调控。
Biomolecules. 2021 Nov 30;11(12):1792. doi: 10.3390/biom11121792.
10
New Look of EBV LMP1 Signaling Landscape.EBV LMP1信号通路的新面貌。
Cancers (Basel). 2021 Oct 29;13(21):5451. doi: 10.3390/cancers13215451.
本文引用的文献
1
Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific.对恶性疟原虫血液阶段自然获得性抗体反应的持续时间取决于年龄且具有抗原特异性。
Infect Immun. 2008 Apr;76(4):1748-55. doi: 10.1128/IAI.01333-07. Epub 2008 Jan 22.
2
CD4 and CD8 T cell responses to tumour-associated Epstein-Barr virus antigens in nasopharyngeal carcinoma patients.鼻咽癌患者中CD4和CD8 T细胞对肿瘤相关爱泼斯坦-巴尔病毒抗原的反应
Cancer Immunol Immunother. 2008 Jul;57(7):963-75. doi: 10.1007/s00262-007-0427-8.
3
AID is required for germinal center-derived lymphomagenesis.生发中心来源的淋巴瘤发生需要AID。
Nat Genet. 2008 Jan;40(1):108-12. doi: 10.1038/ng.2007.35. Epub 2007 Dec 9.
4
Spectrum of Epstein-Barr virus-associated diseases.爱泼斯坦-巴尔病毒相关疾病谱
Annu Rev Pathol. 2006;1:375-404. doi: 10.1146/annurev.pathol.1.110304.100209.
5
Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis.基于CD8 + T细胞肽表位的传染性单核细胞增多症疫苗的I期试验。
J Virol. 2008 Feb;82(3):1448-57. doi: 10.1128/JVI.01409-07. Epub 2007 Nov 21.
6
Burkitt lymphoma: revisiting the pathogenesis of a virus-associated malignancy.伯基特淋巴瘤：重新审视一种病毒相关恶性肿瘤的发病机制。
Hematology Am Soc Hematol Educ Program. 2007:277-84. doi: 10.1182/asheducation-2007.1.277.
7
Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma.恶性疟原虫红细胞膜蛋白1特异性抑制宿主γ干扰素的早期产生。
Cell Host Microbe. 2007 Aug 16;2(2):130-8. doi: 10.1016/j.chom.2007.06.012.
8
Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy.鼻咽癌中EB病毒特异性T淋巴细胞的功能失活：对肿瘤免疫治疗的意义
PLoS One. 2007 Nov 7;2(11):e1122. doi: 10.1371/journal.pone.0001122.
9
A role for AID in chromosome translocations between c-myc and the IgH variable region.活化诱导胞嘧啶脱氨酶（AID）在c-myc与免疫球蛋白重链（IgH）可变区之间染色体易位中的作用。
J Exp Med. 2007 Sep 3;204(9):2225-32. doi: 10.1084/jem.20070884. Epub 2007 Aug 27.
10
A molecular link between malaria and Epstein-Barr virus reactivation.疟疾与爱泼斯坦-巴尔病毒激活之间的分子联系。
PLoS Pathog. 2007 Jun;3(6):e80. doi: 10.1371/journal.ppat.0030080.
Zotero 插件