Arditi-Babchuk Hadar, Feldman Ruth, Eidelman Arthur I
Department of Psychology and the Gonda Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel.
Infant Behav Dev. 2009 Jan;32(1):27-32. doi: 10.1016/j.infbeh.2008.09.001. Epub 2008 Nov 8.
Different aspects of early sleep organization have been associated with subsequent development in premature infants. The aim of the present study was to assess the relations between rapid eye movement (REM) activity in premature neonates and infants' developmental outcomes at 6 months. Participants were 81 premature infants (47 males). Sleep-wake states and REM were observed across 4 consecutive evening hours (7-11 PM) in 10-s frames when infants were between 32 and 36 weeks post-menstrual age. Developmental outcome was assessed at 6 months with the mental development index (MDI) of the Bayley II. Infants with low-REM activity spent more time in less growth-promoting states, including crying and unfocused alert states in the neonatal period and had lower MDI scores at 6 months corrected age compared to infants with high-REM. Differences between the high- and low-REM groups were independent of neonatal medical risk. Low-REM activity may serve as an indicator of developmental risk among premature neonates.
早产婴儿早期睡眠组织的不同方面与随后的发育有关。本研究的目的是评估早产新生儿快速眼动（REM）活动与婴儿6个月时发育结果之间的关系。研究对象为81名早产婴儿（47名男性）。当婴儿处于孕龄32至36周时，在连续4个晚上的7点至11点期间，以10秒为单位观察睡眠-觉醒状态和快速眼动。在6个月时用贝利婴幼儿发展量表第二版（Bayley II）的智力发展指数（MDI）评估发育结果。与快速眼动活动高的婴儿相比，快速眼动活动低的婴儿在促进生长较少的状态下花费的时间更多，包括新生儿期的哭闹和注意力不集中的警觉状态，并且在矫正年龄6个月时MDI得分更低。快速眼动活动高和低的两组之间的差异与新生儿医疗风险无关。快速眼动活动低可能是早产新生儿发育风险的一个指标。
