Department of Pediatrics, University of Minnesota-Twin Cities, Minneapolis, Minnesota.
Department of Neurology, University of Minnesota-Twin Cities, Minneapolis, Minnesota.
J Clin Sleep Med. 2022 Sep 1;18(9):2281-2289. doi: 10.5664/jcsm.10008.
To examine current evidence of the relationship between sleep and pain from the neonatal period through adolescence. This review serves as a critical review of the literature and of the needs for future research on pediatric sleep and pain.
The PubMed online database was queried from January 1, 1960, to March 1, 2020, producing 149 articles applicable to pain and sleep in the pediatric population. Of those, 97 articles were cited in this review with the key articles including over 3800 participants.
The pediatric literature supports the relationship between poor sleep (both sleep efficiency and nighttime awakenings) and subsequent risk for pain, especially among children with chronic disease. The reverse effect of pain on sleep is not yet well delineated. The key moderating factors explored in the literature are pharmacologic and nonpharmacologic therapies, psychologic health, and the etiology of pain. There is evidence that both altered sleep and pain early in life impact neurodevelopment, as seen by changes in sleep structure in clinical studies and alterations in brain development in animal models.
The complicated relationship between sleep and pain is critically important during pediatric development when alterations to a normal sleep structure can have a lifelong impact. It is becoming clear that sleep deprivation and poor sleep quality exacerbate pain. Further research is needed into the complex alterations of sleep in chronic pain conditions as well as treatments to improve sleep in pediatric care.
Morris EE, Howell MJ, Pickup E, Iber C, Wang SG. Pediatric sleep and pain: etiologies, consequences, and clinical considerations. . 2022;18(9):2281-2289.
从新生儿期到青春期，研究睡眠与疼痛之间的现有证据。本综述是对儿科睡眠与疼痛文献的批判性回顾，也是对未来研究的需求进行评估。
从 1960 年 1 月 1 日至 2020 年 3 月 1 日，在 PubMed 在线数据库中进行检索，共获得 149 篇适用于儿科人群疼痛和睡眠的文章。其中，97 篇文章在本综述中被引用，其中关键文章包括 3800 多名参与者。
儿科文献支持睡眠质量差（包括睡眠效率和夜间觉醒）与随后发生疼痛的风险之间的关系，尤其是在患有慢性疾病的儿童中。疼痛对睡眠的反向影响尚未得到很好的描述。文献中探讨的主要调节因素包括药物和非药物治疗、心理健康和疼痛病因。有证据表明，生命早期的睡眠和疼痛改变都会影响神经发育，这在临床研究中观察到睡眠结构改变和动物模型中大脑发育改变中可以体现。
在儿童发育期间，睡眠和疼痛之间复杂的关系非常重要，因为正常的睡眠结构改变可能会产生终身影响。很明显，睡眠剥夺和睡眠质量差会加剧疼痛。需要进一步研究慢性疼痛情况下睡眠的复杂变化以及改善儿科护理中睡眠质量的治疗方法。
Morris EE, Howell MJ, Pickup E, Iber C, Wang SG. Pediatric sleep and pain: etiologies, consequences, and clinical considerations.. 2022;18(9):2281-2289.
