Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A.
作者信息
Takikawa Hirosato, Kamatani Naoki, Nakanishi Kohei, Tashiro Takuya, Sasaki Mitsuru, Yoshida Hiromi, Mizushina Yoshiyuki
机构信息
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Japan.
出版信息
Biosci Biotechnol Biochem. 2008 Nov;72(11):3071-4. doi: 10.1271/bbb.80629. Epub 2008 Nov 7.
PMID:18997393
Abstract
Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.
摘要
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