Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta.
作者信息
Hanashima S, Mizushina Y, Yamazaki T, Ohta K, Takahashi S, Sahara H, Sakaguchi K, Sugawar F
机构信息
Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba, Japan.
出版信息
Bioorg Med Chem. 2001 Feb;9(2):367-76. doi: 10.1016/s0968-0896(00)00252-2.
Abstract
Sulfoquinovosyldiacylglycerols (SQDGs) and sulfoquinovosylmonoacylglycerols (SQMGs), bearing diverse fatty acids, were synthesized from D-glucose, and were examined for enzymatic inhibitions of DNA polymerase alpha and beta. These results indicated that the carbon numbers of the fatty acids were highly related to the activities, at least in vitro, of eukaryotic DNA polymerase inhibition.
摘要
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