Edwards C Q, Griffen L M, Kushner J P
Department of Medicine, LDS Hospital, Salt Lake City, Utah.
Am J Med Sci. 1991 Jan;301(1):50-4. doi: 10.1097/00000441-199101000-00009.
A 35-year-old woman presented with liver failure, hepatic iron overload, and secondary amenorrhea due to hypogonadotropic hypogonadism. She had chronic inflammatory hepatitis which was considered to be due to post-transfusional viral hepatitis. Her hepatic iron overload was considered to be due to hemochromatosis. Her premature menopause was thought to be due to the severity of her liver disease, but her iron overload also could have contributed to gonadotrophin deficiency. She underwent liver transplantation and 5 months later, she experienced return of menstrual function. The distinction between hepatitis as a cause of iron loading, hemochromatosis as a cause of hepatic inflammation, the small influence of alcohol on increased iron stores, and other features of her history, physical examination, and laboratory evaluation are discussed.
一名35岁女性因低促性腺激素性性腺功能减退出现肝衰竭、肝脏铁过载及继发性闭经。她患有慢性炎症性肝炎，被认为是输血后病毒性肝炎所致。她的肝脏铁过载被认为是血色素沉着症所致。她的过早绝经被认为是由于肝脏疾病的严重程度，但她的铁过载也可能导致了促性腺激素缺乏。她接受了肝移植，5个月后月经功能恢复。本文讨论了作为铁负荷原因的肝炎、作为肝脏炎症原因的血色素沉着症、酒精对铁储存增加的微小影响，以及她病史、体格检查和实验室评估的其他特征之间的区别。
