Fukushima Takuya, Horio Kensuke, Matsuo Emi, Imanishi Daisuke, Yamasaki Reishi, Tsushima Hideki, Imaizumi Yoshitaka, Ohshima Koichi, Hata Tomoko, Yoshida Shinichiro, Miyazaki Yasushi, Tomonaga Masao
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
Int J Hematol. 2008 Dec;88(5):596-598. doi: 10.1007/s12185-008-0190-4. Epub 2008 Nov 8.
A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second transplantation following myeloablative conditioning brought complete remission (CR), but relapse of MF occurred 3 months after transplantation. However, discontinuation of immune suppressant led to the regression of MF regions and to second CR that continued for more than 23 months. This is the first report of successful CBT for MF, suggesting the graft-versus-MF effect in a setting of CBT.
一名26岁女性被诊断为蕈样肉芽肿（MF，临床IV期），先后接受了单药化疗、多药化疗以及采用减低剂量预处理的非亲缘骨髓移植（植入失败），均告失败。在清髓性预处理后进行的非亲缘脐血移植（CBT）作为第二次移植带来了完全缓解（CR），但移植后3个月MF复发。然而，停用免疫抑制剂导致MF区域消退并再次获得持续超过23个月的CR。这是首例关于MF成功接受CBT的报告，提示在CBT情况下存在移植物抗MF效应。
