Wang Chun-Nian, Zhao Fei-Xing, Ni Tong, Zhou Hang-Bo, Lu Zhen-Feng, Shi Qun-Li
Department of Pathology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2008 Sep;14(9):810-4.
To investigate the clinical pathological characteristics, diagnosis and differential diagnosis of Paget's disease of the scrotum and penis.
Thirteen cases of Paget's disease of the scrotum and penis were analyzed by light microscopy, alcian-blue (AB)/periodic-acid-Schiff (PAS) and immunohistochemical staining.
Paget's disease of the scrotum and penis mainly affected old individuals aged 55-84 (mean 71) years. Macroscopically, typical presentations of Paget's disease of the scrotum and penis were eczematoid lesions. Microscopically, Paget cells were distributed singly or in groups (as strands, nests or glandular patterns) within the epidermis. Paget cells were typically stained for AB/PAS, positive for CK7, CEA and EMA, and negative for CK5/6, S-100 and P63. The positive rates of GCDFP-15 and CK20 expressions were 76.92% (10/13)and 53.85% (7/13) respectively.
Paget's disease of the scrotum and penis is a low-malignancy cutaneous tumor with typical clinical and pathological features. Pathologic diagnosis is based on immunohistochemical findings.
探讨阴囊及阴茎佩吉特病的临床病理特征、诊断及鉴别诊断。
对13例阴囊及阴茎佩吉特病患者进行光镜、阿尔辛蓝（AB）/过碘酸希夫（PAS）及免疫组化染色分析。
阴囊及阴茎佩吉特病主要累及55 - 84岁（平均71岁）的老年人。大体上，阴囊及阴茎佩吉特病的典型表现为湿疹样病变。镜下，佩吉特细胞在表皮内单个或成群分布（呈条索状、巢状或腺管状）。佩吉特细胞AB/PAS染色呈阳性，细胞角蛋白7（CK7）、癌胚抗原（CEA）和上皮膜抗原（EMA）呈阳性，细胞角蛋白5/6（CK5/6）、S - 100和P63呈阴性。GCDFP - 15和CK20表达的阳性率分别为76.92%（10/13）和53.85%（7/13）。
阴囊及阴茎佩吉特病是一种具有典型临床和病理特征的低恶性皮肤肿瘤。病理诊断基于免疫组化结果。
