Henning J Scott
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
J Drugs Dermatol. 2006 Jul-Aug;5(7):652-4.
A 64-year-old Chinese man presented to the Bellevue Hospital Center Department of Dermatology with a 2-year history of an enlarging mass in his suprapubic region, which measured 7 cm x 9 cm and involved the penis and scrotum. A biopsy specimen showed extramammary Paget's disease. Twenty years earlier, while living in China in 1983, this patient had a suprapubic skin cancer which was excised, and he received radiation to the region. Extramammary Paget's disease is a rare cutaneous adenocarcinoma of epidermal origin, which is frequently associated with adnexal carcinoma and internal malignant conditions. Clinically, extramammary Paget's disease is characterized by a red, moist, eroded plaque in the anogenital region. Extramammary Paget's disease usually behaves as a slow-growing intraepithelial adenocarcinoma; however, it may become invasive and may metastasize through dermal lymphatics. The treatment of choice is wide excision.
一名64岁的中国男性因耻骨上区肿物增大2年就诊于贝尔维尤医院中心皮肤科。该肿物大小为7厘米×9厘米，累及阴茎和阴囊。活检标本显示为乳房外佩吉特病。20年前，即1983年在中国时，该患者曾患耻骨上皮肤癌，已行切除，并接受了该区域的放射治疗。乳房外佩吉特病是一种罕见的起源于表皮的皮肤腺癌，常与附属器癌和体内恶性疾病相关。临床上，乳房外佩吉特病的特征是在肛门生殖器区域出现红色、湿润、糜烂的斑块。乳房外佩吉特病通常表现为生长缓慢的上皮内腺癌；然而，它可能会侵袭并可能通过真皮淋巴管转移。首选的治疗方法是广泛切除。
