Linday Linda A, Shindledecker Richard D, Dolitsky Jay N, Chen Tai C, Holick Michael F
Department of Otolaryngology, The New York Eye and Ear Infirmary, NY, USA.
Ann Otol Rhinol Laryngol. 2008 Oct;117(10):740-4. doi: 10.1177/000348940811701006.
We report the plasma 25-hydroxyvitamin D [25(OH)D] levels of 16 young children who were undergoing ambulatory surgery for placement of tympanostomy tubes.
We previously obtained blood samples from young children who were undergoing ambulatory surgery and reported that they had lower blood levels than adults of eicosapentaenoic acid (an omega-3 fatty acid), vitamin A, and selenium. Plasma frozen continuously at -80 degrees C was available from 16 subjects who were undergoing placement of tympanostomy tubes.
The mean (+/- SD) age of the patients was 3.7 +/- 1.6 years (median, 2.9 years; range, 1.9 to 7.4 years). Sixty-two percent were male; half were white, and half were Hispanic. Sixty-two percent were private patients; the parents reported that half were taking vitamin supplements. None had a history of rickets. None had 25(OH)D levels less than 10 ng/mL; 50% had 25(OH)D levels less than 20 ng/mL (deficient in adults); another 31% had levels from 21 to 29 ng/mL (insufficient in adults).
Vitamin D is essential for the production of endogenous antimicrobial peptides, and has been linked to seasonal, epidemic influenza A. However, the level of 25(OH)D needed to prevent infection with various human pathogens has not been defined. In view of increasing bacterial resistance and emerging new pathogens, further research on the relationship of infection to 25(OH)D and other nutritional factors is warranted.
我们报告了16名正在接受鼓膜置管门诊手术的幼儿的血浆25-羟基维生素D[25(OH)D]水平。
我们之前从正在接受门诊手术的幼儿身上采集了血样，并报告他们的二十碳五烯酸（一种ω-3脂肪酸）、维生素A和硒的血液水平低于成年人。从16名正在接受鼓膜置管手术的受试者中获取了一直保存在-80摄氏度下冷冻的血浆。
患者的平均（±标准差）年龄为3.7±1.6岁（中位数为2.9岁；范围为1.9至7.4岁）。62%为男性；一半是白人，一半是西班牙裔。62%是自费患者；父母报告说其中一半在服用维生素补充剂。没有人有佝偻病病史。没有人的25(OH)D水平低于10 ng/mL；50%的人25(OH)D水平低于20 ng/mL（在成年人中为缺乏）；另外31%的人水平在21至29 ng/mL之间（在成年人中为不足）。
维生素D对于内源性抗菌肽的产生至关重要，并且与季节性甲型流行性感冒有关。然而，预防各种人类病原体感染所需的25(OH)D水平尚未确定。鉴于细菌耐药性的增加和新病原体的出现，有必要进一步研究感染与25(OH)D及其他营养因素之间的关系。
