催化对映选择性迈尔外因-埃申莫泽克莱森重排反应：烯丙基羟吲哚的不对称合成
Catalytic enantioselective Meerwein-Eschenmoser Claisen rearrangement: asymmetric synthesis of allyl oxindoles.
作者信息
Linton Elizabeth C, Kozlowski Marisa C
机构信息
Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
出版信息
J Am Chem Soc. 2008 Dec 3;130(48):16162-3. doi: 10.1021/ja807026z.
PMID:18998679
Abstract
The first catalytic, enantioselective Meerwein-Eschenmoser Claisen rearrangement has been achieved. Palladium(II) BINAP or phosphinooxazoline catalysts were employed to generate oxindole products with 100% conversion and up to 92% ee.
摘要
首次实现了催化对映选择性的迈尔外因-埃申莫泽克莱森重排反应。使用钯（II）联萘二膦或膦基恶唑啉催化剂生成了转化率达100%且对映体过量高达92%的氧化吲哚产物。
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