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Mutagenicity of oxygen free radicals.氧自由基的致突变性。
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2
Age pigments: role of iron and copper salts in the formation of fluorescent lipid complexes.老年色素：铁盐和铜盐在荧光脂质复合物形成中的作用
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DNA damage by superoxide-generating systems in relation to the mechanism of action of the anti-tumour antibiotic adriamycin.超氧化物生成系统导致的DNA损伤与抗肿瘤抗生素阿霉素的作用机制的关系
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Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: a physiologically significant reaction?在铜盐存在下超氧化物依赖性和抗坏血酸依赖性羟基自由基的形成：一种具有生理意义的反应？
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DNA strand scission by enzymically generated oxygen radicals.酶促产生的氧自由基导致DNA链断裂。
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在过氧化氢存在的情况下，铜离子对DNA碱基的依赖性损伤。

Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide.

作者信息

Aruoma O I, Halliwell B, Gajewski E, Dizdaroglu M

机构信息

Department of Biochemistry, University of London King's College, U.K.

出版信息

Biochem J. 1991 Feb 1;273 ( Pt 3)(Pt 3):601-4. doi: 10.1042/bj2730601.

DOI:10.1042/bj2730601
PMID:1899997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1149805/
Abstract

Mixtures of Cu2+ and H2O2 at pH 7.4 caused damage to the bases in DNA greater than that caused by mixtures of Fe3+ and H2O2. Addition of ascorbic acid to the Cu2+/H2O2 system caused a very large increase in base damage, much greater than that produced by the Fe3+/H2O2/ascorbic acid system. The products of base damage in the presence of Cu2+ were typical products that have been shown to result from attack of hydroxyl radicals upon the DNA bases. Cytosine glycol, thymine glycol, 8-hydroxyadenine and especially 8-hydroxyguanine were the major products in both the Cu2+/H2O2 and the Cu2+/H2O2/ascorbic acid systems. Base damage in DNA by these systems was inhibited by the chelating agents EDTA and nitrilotriacetic acid and by catalase, but not by superoxide dismutase, nor by the hydroxyl-radical scavenger mannitol. It is proposed that Cu2+ ions bound to the DNA react with H2O2 and ascorbic acid to generate hydroxyl radicals, which then immediately attack the DNA bases in a site-specific manner. A hypoxanthine/xanthine oxidase system also caused damage to the DNA bases in the presence of Cu2+ ions. This was inhibited by superoxide dismutase and catalase. The high activity of Cu2+ ions, when compared with Fe3- ions, in causing hydroxyl-radical-dependent damage to DNA and to other biomolecules, means that the availability of Cu2+ ions in vivo must be carefully controlled.

摘要

在pH 7.4条件下，Cu2+与H2O2的混合物对DNA碱基造成的损伤大于Fe3+与H2O2的混合物。向Cu2+/H2O2体系中添加抗坏血酸会导致碱基损伤大幅增加，比Fe3+/H2O2/抗坏血酸体系产生的损伤大得多。在Cu2+存在的情况下，碱基损伤的产物是典型产物，已证明是由羟基自由基攻击DNA碱基所致。胞嘧啶二醇、胸腺嘧啶二醇、8-羟基腺嘌呤，尤其是8-羟基鸟嘌呤是Cu2+/H2O2体系和Cu2+/H2O2/抗坏血酸体系中的主要产物。这些体系对DNA的碱基损伤受到螯合剂乙二胺四乙酸（EDTA）和次氮基三乙酸以及过氧化氢酶的抑制，但不受超氧化物歧化酶和羟基自由基清除剂甘露醇的抑制。有人提出，与DNA结合的Cu2+离子与H2O2和抗坏血酸反应生成羟基自由基，然后羟基自由基立即以位点特异性方式攻击DNA碱基。次黄嘌呤/黄嘌呤氧化酶体系在Cu2+离子存在的情况下也会对DNA碱基造成损伤，这受到超氧化物歧化酶和过氧化氢酶的抑制。与Fe3+离子相比，Cu2+离子在导致依赖羟基自由基对DNA和其他生物分子造成损伤方面具有较高活性，这意味着必须严格控制体内Cu2+离子的可用性。