氧自由基的致突变性。
Mutagenicity of oxygen free radicals.
作者信息
Moody C S, Hassan H M
出版信息
Proc Natl Acad Sci U S A. 1982 May;79(9):2855-9. doi: 10.1073/pnas.79.9.2855.
Abstract
Paraquat (1,1'-dimethyl-4,4'-bipyridinium dichloride) was used as an intracellular generator of oxygen free radicals and was found to be highly mutagenic for Salmonella typhimurium. It caused both base-pair substitution and frameshift mutations. Paraquat was much more toxic and mutagenic in a simple nutritionally restricted medium than in a rich complex medium. The mutagenicity of paraquat was dependent upon the presence of a supply of both electrons and oxygen. Cells containing high levels of superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) were more resistant to the toxicity and the mutagenicity of paraquat than were cells containing normal levels of this enzyme. The mutagenicity of paraquat thus appears to be due to its ability to exacerbate the intracellular production of superoxide radicals.
摘要
百草枯（1,1'-二甲基-4,4'-联吡啶二氯化物）被用作细胞内氧自由基的产生剂，并且发现它对鼠伤寒沙门氏菌具有高度致突变性。它会引起碱基对替换和移码突变。在简单的营养受限培养基中，百草枯的毒性和致突变性比在丰富的复合培养基中要强得多。百草枯的致突变性取决于电子和氧气供应的存在。含有高水平超氧化物歧化酶（超氧化物：超氧化物氧化还原酶，EC 1.15.1.1）的细胞比含有正常水平该酶的细胞对百草枯的毒性和致突变性更具抗性。因此，百草枯的致突变性似乎是由于其加剧细胞内超氧自由基产生的能力。
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