Gutteridge J M
Mech Ageing Dev. 1984 Apr-May;25(1-2):205-14. doi: 10.1016/0047-6374(84)90141-6.
Free radicals which abstract hydrogen atoms from unsaturated fatty acids initiate lipid autoxidation. Transition metal ions, however, usually stimulate lipid autoxidation by decomposing peroxides to release active radicals which can then initiate further autoxidation. Lipid peroxides produced in vivo, both enzymically and non-enzymically, are probably decomposed in this way resulting in the formation of fluorescent lipid complexes. The role of iron and copper salts in their formation has been studied using sequential techniques on fatty acid and phospholipid preparations.
从不饱和脂肪酸中夺取氢原子的自由基引发脂质自氧化。然而，过渡金属离子通常通过分解过氧化物以释放活性自由基来刺激脂质自氧化，这些活性自由基随后可引发进一步的自氧化。体内通过酶促和非酶促方式产生的脂质过氧化物可能以这种方式分解，从而导致形成荧光脂质复合物。利用对脂肪酸和磷脂制剂的连续技术研究了铁盐和铜盐在其形成过程中的作用。
