Tashima Yoshihiko, Hamada Hiroyuki, Okamoto Masahiro, Hanai Taizo
Laboratory for Bioinformatics, Graduate School of Systems Life Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
J Biosci Bioeng. 2008 Oct;106(4):368-74. doi: 10.1263/jbb.106.368.
Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-dependent kinases, and other proteins. Numerical simulation techniques and system analysis are expected to become powerful tools for investigating complex biological networks. To reach this goal, we designed a mathematical model of the G1/S phase transition. Using our model, we conducted a numerical simulation and comprehensive system analyses of this phase of the cell cycle. In this way, we were able to predict the key factors involved in the control of the G1/S transition.
细胞周期G1/S期转换的调控有助于维持体内稳态。众所周知，细胞周期的紊乱与细胞转化和致癌作用有关。G1/S期转换涉及一个由细胞周期蛋白、细胞周期蛋白依赖性激酶和其他蛋白质组成的网络。数值模拟技术和系统分析有望成为研究复杂生物网络的有力工具。为了实现这一目标，我们设计了一个G1/S期转换的数学模型。利用我们的模型，我们对细胞周期的这一阶段进行了数值模拟和全面的系统分析。通过这种方式，我们能够预测参与G1/S转换调控的关键因素。
