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Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells.黄连提取物增强雌激素受体拮抗剂对人乳腺癌细胞的抗癌作用。
Biochem Biophys Res Commun. 2009 Jan 9;378(2):174-8. doi: 10.1016/j.bbrc.2008.10.169. Epub 2008 Nov 8.
2
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Climacteric. 2008 Aug;11(4):315-21. doi: 10.1080/13697130802232500.
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The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells.雌激素受体影响微管相关蛋白 tau（MAPT）的表达，而选择性雌激素受体抑制剂氟维司群下调 MAPT 的表达，并增加乳腺癌细胞对紫杉烷的敏感性。
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本文引用的文献

1
Inflammation and cancer prevention.炎症与癌症预防。
Ann Oncol. 2008 Sep;19 Suppl 7:vii225-9. doi: 10.1093/annonc/mdn442.
2
Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.信号转导及转录激活因子5b、c-Src和表皮生长因子受体信号传导在雌激素刺激的雌激素受体阳性乳腺癌细胞增殖中发挥着不可或缺的作用。
Mol Endocrinol. 2008 Aug;22(8):1781-96. doi: 10.1210/me.2007-0419. Epub 2008 Jun 11.
3
The role of selective estrogen receptor modulators on breast cancer: from tamoxifen to raloxifene.选择性雌激素受体调节剂在乳腺癌中的作用：从他莫昔芬到雷洛昔芬。
Taiwan J Obstet Gynecol. 2008 Mar;47(1):24-31. doi: 10.1016/S1028-4559(08)60051-0.
4
Tamoxifen-stimulated growth of breast cancer due to p21 loss.由于p21缺失导致他莫昔芬刺激乳腺癌生长。
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):288-93. doi: 10.1073/pnas.0710887105. Epub 2007 Dec 27.
5
Tamoxifen: catalyst for the change to targeted therapy.他莫昔芬：靶向治疗变革的催化剂。
Eur J Cancer. 2008 Jan;44(1):30-8. doi: 10.1016/j.ejca.2007.11.002.
6
Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells.黄连素对低密度脂蛋白（LDL）氧化及氧化型LDL诱导的内皮细胞细胞毒性的保护作用。
J Agric Food Chem. 2007 Dec 12;55(25):10437-45. doi: 10.1021/jf071868c. Epub 2007 Nov 15.
7
Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies.克服对分子靶向抗癌疗法的耐药性：基于EGFR和MAPK抑制的实体瘤和血液系统恶性肿瘤的合理联合用药
Drug Resist Updat. 2007 Jun;10(3):81-100. doi: 10.1016/j.drup.2007.03.003. Epub 2007 May 7.
8
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor.使用表皮生长因子受体-人表皮生长因子受体2/neu双重抑制剂和Bcl-2抑制剂对乳腺癌细胞系进行协同抑制
Oncol Rep. 2007 Feb;17(2):465-9.
9
Overexpression of c-Myc and Bcl-2 during progression and distant metastasis of hormone-treated breast cancer.c-Myc和Bcl-2在激素治疗的乳腺癌进展和远处转移过程中的过表达。
Exp Mol Pathol. 2007 Feb;82(1):85-90. doi: 10.1016/j.yexmp.2006.09.001. Epub 2006 Oct 13.
10
Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00).氟维司群对晚期乳腺癌且对芳香化酶抑制剂原发性或获得性耐药的绝经后女性的临床获益：瑞士临床癌症研究组II期试验（SAKK 21/00）的最终结果
Ann Oncol. 2007 Jan;18(1):64-69. doi: 10.1093/annonc/mdl341. Epub 2006 Oct 9.

黄连提取物增强雌激素受体拮抗剂对人乳腺癌细胞的抗癌作用。

Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells.

作者信息

Liu Jing, He Chengwei, Zhou Keyuan, Wang Jingdong, Kang Jing X

机构信息

Departmement of Medicine, Massachusetts General Hospital and Harvard Medical School, 149 - 13th Street, Room 4433, Charlestown, MA 02129, USA.

出版信息

Biochem Biophys Res Commun. 2009 Jan 9;378(2):174-8. doi: 10.1016/j.bbrc.2008.10.169. Epub 2008 Nov 8.

DOI:10.1016/j.bbrc.2008.10.169
PMID:19000652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3454467/
Abstract

Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment, but the efficacy and drug resistance remain to be clinical concerns. The purpose of this study was to determine whether the extracts of coptis, an anti-inflammatory herb, improve the anticancer efficacy of ER antagonists. The results showed that the combined treatment of ER antagonists and the crude extract of coptis or its purified compound berberine conferred synergistic growth inhibitory effect on MCF-7 cells (ER+), but not on MDA-MB-231 cells (ER-). Similar results were observed in the combined treatment of fulvestrant, a specific aromatase antagonist. Analysis of the expression of breast cancer related genes indicated that EGFR, HER2, bcl-2, and COX-2 were significantly downregulated, while IFN-beta and p21 were remarkably upregulated by berberine. Our results suggest that coptis extracts could be promising adjuvant to ER antagonists in ER positive breast cancer treatment through regulating expression of multiple genes.

摘要

雌激素受体（ER）拮抗剂已被广泛用于乳腺癌治疗，但疗效和耐药性仍是临床关注的问题。本研究的目的是确定抗炎草药黄连的提取物是否能提高ER拮抗剂的抗癌疗效。结果表明，ER拮抗剂与黄连粗提物或其纯化化合物黄连素联合治疗对MCF-7细胞（ER+）具有协同生长抑制作用，但对MDA-MB-231细胞（ER-）无此作用。在特异性芳香化酶拮抗剂氟维司群的联合治疗中也观察到了类似结果。对乳腺癌相关基因表达的分析表明，黄连素可显著下调EGFR、HER2、bcl-2和COX-2的表达，同时显著上调IFN-β和p21的表达。我们的结果表明，黄连提取物可能通过调节多个基因的表达，成为ER阳性乳腺癌治疗中ER拮抗剂的有前景的辅助药物。