Raymond J, Cohen R
Service de Bactériologie, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris cedex 19, France.
Arch Pediatr. 2008 Oct;15 Suppl 2:S59-61. doi: 10.1016/S0929-693X(08)74217-9.
Two bacterial species are responsible for the majority of children skin infections: Streptococcus pyogenes and Staphylococcus aureus. If S. pyogenes remain susceptible to the beta-lactams, their resistance to macrolides varies over time but remains significant (> 10%). In France, most resistant strains are by modification of the target, coded by the gene erm b. For S. aureus, almost all strains isolated were resistant to G and A penicillins, but remain susceptible to M penicillin and cephalosporins. In France, the incidence of methicillin resistant community acquired S. aureus strains is currently low, around 6 %, but the risk of a rapid increase is real.
化脓性链球菌和金黄色葡萄球菌。如果化脓性链球菌对β-内酰胺类药物仍敏感，它们对大环内酯类药物的耐药性会随时间变化，但仍很显著（>10%）。在法国，大多数耐药菌株是通过由erm b基因编码的靶点修饰产生的。对于金黄色葡萄球菌，几乎所有分离出的菌株都对G型和A型青霉素耐药，但对M型青霉素和头孢菌素仍敏感。在法国，耐甲氧西林社区获得性金黄色葡萄球菌菌株的发病率目前较低，约为6%，但确实存在迅速上升的风险。
