Oliveria Susan A, Satagopan Jaya M, Geller Alan C, Dusza Stephen W, Weinstock Martin A, Berwick Marianne, Bishop Marilyn, Heneghan Maureen K, Halpern Allan C
Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA.
Am J Epidemiol. 2009 Jan 1;169(1):41-53. doi: 10.1093/aje/kwn289. Epub 2008 Nov 10.
The authors report baseline findings and predictors of nevus count (log total nevi) at the completion of year 1 (2004) of the first known population-based, prospective study of nevi in a US cohort of children. Overall, 64% (n = 443/691) of grade 5 students and their parents in Framingham, Massachusetts, completed surveys and underwent digital photography. Total nevus count was associated with skin and hair color and tendency to burn, as measured by a sun sensitivity index. In multivariate analyses, male gender (rate ratio (RR) = 1.38, 95% confidence interval (CI): 1.22, 1.55; P < 0.0001), spending 5-6 weekly hours outdoors between 10 AM and 4 PM (RR = 1.13, 95% CI: 1.00, 1.28; P = 0.051), getting a painful sunburn once (RR = 1.24, 95% CI: 0.98, 1.57; P = 0.073) and at least twice (RR = 1.34, 95% CI: 0.99, 1.82; P = 0.061), and wearing a shirt at the beach or pool rarely (RR = 1.29, 95% CI: 1.08, 1.54; P = 0.005), sometimes (RR = 1.26, 95% CI: 1.01, 1.57; P = 0.041), and often and always (RR = 1.32, 95% CI: 1.13, 1.54; P = 0.001) were associated with increased number of nevi. Identifying factors that predict the development of nevi will improve primary prevention efforts during early life.
作者报告了在美国一组儿童中进行的首次基于人群的痣前瞻性研究第1年（2004年）结束时痣计数（痣总数的对数）的基线结果和预测因素。总体而言，马萨诸塞州弗雷明汉姆的64%（n = 443/691）五年级学生及其父母完成了调查并接受了数码摄影。通过阳光敏感性指数测量，痣总数与皮肤和头发颜色以及晒伤倾向相关。在多变量分析中，男性（率比（RR）= 1.38，95%置信区间（CI）：1.22，1.55；P < 0.0001）、上午10点至下午4点之间每周在户外度过5 - 6小时（RR = 1.13，95% CI：1.00，1.28；P = 0.051）、曾有一次（RR = 1.24，95% CI：0.98，1.57；P = 0.073）和至少两次（RR = 1.34，95% CI：0.99，1.82；P = 0.061）晒伤疼痛、在海滩或泳池很少（RR = 1.29，95% CI：1.08，1.54；P = 0.005）、有时（RR = 1.26，95% CI：1.01，1.57；P = 0.041）以及经常和总是（RR = 1.32，95% CI：1.13，1.54；P = 0.001）穿衬衫与痣数量增加相关。识别预测痣发展的因素将改善早期生活中的一级预防工作。
