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Rapid iron loading in heart and liver in a patient with transfusion dependent thalassaemia after brief poor compliance with iron chelation therapy.一名依赖输血的地中海贫血患者在短暂不依从铁螯合治疗后，心脏和肝脏中铁快速蓄积。
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Deferasirox (Exjade) significantly improves cardiac T2* in heavily iron-overloaded patients with beta-thalassemia major.地拉罗司（Exjade）可显著改善重型β-地中海贫血患者的心脏 T2*。
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本文引用的文献

1
Onset of cardiac iron loading in pediatric patients with thalassemia major.重型地中海贫血患儿心脏铁负荷的发生
Haematologica. 2008 Jun;93(6):917-20. doi: 10.3324/haematol.12513. Epub 2008 Apr 15.
2
Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction.重型地中海贫血联合螯合疗法治疗重度心肌铁沉着症伴左心室功能障碍。
J Cardiovasc Magn Reson. 2008 Feb 25;10(1):12. doi: 10.1186/1532-429X-10-12.
3
A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance.一项使用心血管磁共振评估去铁胺与去铁酮联合治疗对重型地中海贫血患者心肌铁影响的随机、安慰剂对照、双盲试验。
Circulation. 2007 Apr 10;115(14):1876-84. doi: 10.1161/CIRCULATIONAHA.106.648790. Epub 2007 Mar 19.
4
Glutathione S-transferase M1 gene polymorphisms are associated with cardiac iron deposition in patients with beta-thalassemia major.谷胱甘肽S-转移酶M1基因多态性与重型β地中海贫血患者心脏铁沉积有关。
Hemoglobin. 2006;30(2):251-6. doi: 10.1080/03630260600642575.
5
Low serum ferritin levels are misleading for detecting cardiac iron overload and increase the risk of cardiomyopathy in thalassemia patients. The importance of cardiac iron overload monitoring using magnetic resonance imaging T2 and T2*.低血清铁蛋白水平在检测地中海贫血患者的心脏铁过载时具有误导性，并增加了心肌病的风险。使用磁共振成像T2和T2*监测心脏铁过载的重要性。
Hemoglobin. 2006;30(2):219-27. doi: 10.1080/03630260600642542.
6
Myocardial iron loading in patients with thalassemia major on deferoxamine chelation.接受去铁胺螯合治疗的重型地中海贫血患者的心肌铁负荷
J Cardiovasc Magn Reson. 2006;8(3):543-7. doi: 10.1080/10976640600698155.
7
Combined therapy with desferrioxamine and deferiprone in beta thalassemia major patients with transfusional iron overload.去铁胺与去铁酮联合治疗重型β地中海贫血输血性铁过载患者。
Ann Hematol. 2006 May;85(5):315-9. doi: 10.1007/s00277-005-0075-z. Epub 2006 Feb 1.
8
Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major.接受去铁胺或去铁酮治疗的重型地中海贫血患者的心脏发病率和死亡率。
Blood. 2006 May 1;107(9):3733-7. doi: 10.1182/blood-2005-07-2933. Epub 2005 Dec 22.
9
Evaluation of iron overload.铁过载评估
Br J Haematol. 2004 Mar;124(6):697-711. doi: 10.1111/j.1365-2141.2004.04838.x.
10
Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload.心血管T2*（T2*）磁共振成像用于心肌铁过载的早期诊断。
Eur Heart J. 2001 Dec;22(23):2171-9. doi: 10.1053/euhj.2001.2822.

T2* cardiovascular magnetic resonance in the management of thalassemia patients in Oman.

作者信息

Daar Shahina, Pathare Anil V, Jain Rajeev, Zadjali Shoaib Al, Pennell Dudley J

出版信息

Haematologica. 2009 Jan;94(1):140-1. doi: 10.3324/haematol.13845. Epub 2008 Nov 10.

DOI:10.3324/haematol.13845
PMID:19001285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2625422/
Abstract
摘要