人肝脏4-甲基伞形酮UDP-葡萄糖醛酸基转移酶活性的药物抑制剂特异性评估。
Assessment of the drug inhibitor specificity of the human liver 4-methylumbelliferone UDP-glucuronosyltransferase activity.
作者信息
Miners J O, Lillywhite K J
机构信息
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, Australia.
出版信息
Biochem Pharmacol. 1991 Mar 1;41(5):838-41. doi: 10.1016/0006-2952(91)90090-r.
PMID:1900159
Abstract
The data suggest that the 4MU-UDPGT activity of human liver microsomes probably contributes to the glucuronidation of a limited number of clinically used drugs. However, confirmation of this ultimately requires studies to be performed with purified isozymes, cDNAs expressed in cell culture, or specific inhibitory antibodies.
摘要
数据表明，人肝微粒体的4MU-UDPGT活性可能有助于少数临床使用药物的葡萄糖醛酸化。然而，最终证实这一点需要使用纯化的同工酶、在细胞培养中表达的cDNA或特异性抑制抗体进行研究。
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