Assessment of the drug inhibitor specificity of the human liver 4-methylumbelliferone UDP-glucuronosyltransferase activity.
作者信息
Miners J O, Lillywhite K J
机构信息
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, Australia.
出版信息
Biochem Pharmacol. 1991 Mar 1;41(5):838-41. doi: 10.1016/0006-2952(91)90090-r.
PMID:1900159
Abstract
The data suggest that the 4MU-UDPGT activity of human liver microsomes probably contributes to the glucuronidation of a limited number of clinically used drugs. However, confirmation of this ultimately requires studies to be performed with purified isozymes, cDNAs expressed in cell culture, or specific inhibitory antibodies.
摘要
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