Wang Gong-ping, Yang Bo, Guan Fang-xia, DU Ying, Chang Ke-liang, Song Lai-jun, Hu Xiang, Zeng Guang-wei
Department of Neurosurgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052û Department of Tumor, First Affiliated Hospital, Henan University of Science and Technology, Luoyang Henan 471003, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Oct;33(10):926-30.
To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways.
Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n=20) and a treatment group(n=60) which were further evenly divided into Group A (transplanted through the vena caudalis), Group B (transplanted through the ventriculus cerebri lateralis), and Group C (transplanted through the injured brain area). Each group was transplanted with amniotic-derived esenchymal stem cells, and their therapeutic efficacy would be evaluated through the neurological severity score (NSS).
Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P<0.05). Compared with the control group, the behaviors of Group A and Group B had marked improvement. There was statistically significant difference in the 3 groups (P<0.05). However, there was no significant difference between Group A and the control group (P>0.05).
Transplanting the amniotic-derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.
通过以不同方式将羊膜间充质干细胞移植到脑损伤大鼠体内，比较行为改善情况以找到治疗脑损伤的最佳移植方法。
80只脑损伤的Wista大鼠被随机分为单纯脑损伤对照组（n = 20）和治疗组（n = 60），治疗组再平均分为A组（经尾静脉移植）、B组（经侧脑室移植）和C组（经损伤脑区移植）。每组均移植羊膜间充质干细胞，并通过神经功能缺损评分（NSS）评估其治疗效果。
与其他组相比，C组大鼠行为改善明显。两组间差异有统计学意义（P < 0.05）。与对照组相比，A组和B组大鼠行为有明显改善。三组间差异有统计学意义（P < 0.05）。然而，A组与对照组之间差异无统计学意义（P > 0.05）。
将羊膜间充质干细胞移植到损伤脑区可能对大鼠脑损伤有效。
