Briggs D, Zehnder D, Higgins R M
Histocompatibility Laboratory, NHS Blood and Transplant, Birmingham, UK.
Contrib Nephrol. 2009;162:107-16. doi: 10.1159/000170843. Epub 2008 Oct 31.
Patients undergoing renal transplantation frequently have non-donor-specific HLA antibodies (NDSA). There could be NDSA (e.g. a negative crossmatch in a sensitized patient), or could be donor-specific HLA antibodies (DSA) (e.g., antibody-incompatible transplantation). NDSA levels slowly fall in the first month after transplantation, but in some patients their levels initially rise during a rejection episode with increased synthesis of DSA. This could be due to antibodies binding with shared epitopes on donor-specific and non-donor-specific HLA, or due to non-specific immune upregulation. Further investigation of the levels of NDSA in the context of the levels of DSA and other immunoglobulins will lead to new insights into the control of DSA responses.
接受肾移植的患者经常会产生非供体特异性HLA抗体（NDSA）。可能存在NDSA（例如，致敏患者的交叉配型阴性），也可能是供体特异性HLA抗体（DSA）（例如，抗体不相容移植）。NDSA水平在移植后的第一个月会缓慢下降，但在一些患者中，其水平在排斥反应期间最初会随着DSA合成增加而上升。这可能是由于抗体与供体特异性和非供体特异性HLA上的共享表位结合，或者是由于非特异性免疫上调。在DSA水平和其他免疫球蛋白水平的背景下进一步研究NDSA水平将为控制DSA反应带来新的见解。
