Qu Fan, Zhou Jue, Burrows Elizabeth, Luo Qiong, Wu Yanting, Wang Tingting, Huang Hefeng
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Forsch Komplementmed. 2008 Oct;15(5):282-5. doi: 10.1159/000159274. Epub 2008 Oct 6.
The aim of the present study was to explore whether acupuncture may improve the absorption of baicalin from the extracts of Scutellaria baicalensis Georgi in rats with pelvic inflammation. 24 female Sprague-Dawley (SD) rats were randomly divided into groups A (a combination of oral administration of Scutellaria baicalensis Georgi extracts and acupuncture), B (oral administration of Scutellaria baicalensis Georgi extracts), C (model group) and D (normal control group), with 6 rats in each group. After treatment, the plasma concentration of baicalin was determined using high performance liquid chromatography (HPLC), the serum levels of tumor necrosis factor-alpha (TNF-alpha) and Interleukin 6 (IL-6) were detected with enzyme-linked immunosorbent assay (ELISA). The results showed that the plasma concentration of baicalin in group A was significantly higher than in group B, and the serum levels of TNF-alpha and IL-6 in group A were significantly lower than in group B. This indicates that acupuncture at certain acupoints may significantly improve the curative effects of Scutellaria baicalensis Georgi in rats with pelvic inflammation by enhancing the absorption of baicalin from the Scutellaria baicalensis Georgi extracts.
本研究的目的是探讨针刺是否可以提高黄芩提取物中黄芩苷在盆腔炎大鼠体内的吸收。将24只雌性Sprague-Dawley（SD）大鼠随机分为A组（口服黄芩提取物并针刺）、B组（口服黄芩提取物）、C组（模型组）和D组（正常对照组），每组6只大鼠。治疗后，采用高效液相色谱法（HPLC）测定黄芩苷的血浆浓度，用酶联免疫吸附测定法（ELISA）检测肿瘤坏死因子-α（TNF-α）和白细胞介素6（IL-6）的血清水平。结果显示，A组黄芩苷的血浆浓度显著高于B组，A组TNF-α和IL-6的血清水平显著低于B组。这表明针刺某些穴位可能通过增强大鼠对黄芩提取物中黄芩苷的吸收，显著提高黄芩对盆腔炎大鼠的治疗效果。
