Zhou Jue, Qu Fan, Yu Yongping, Nan Rui
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):103-8. doi: 10.4314/ajtcam.v6i1.57080.
The research was to explore whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi (Scutellaria baicalensis) in treating models rats with pelvic inflammation. Twelve model rats were randomized into a Scutellaria baicalensis group and a Scutellaria baicalensis+garlic group with six in each group for pharmacokinetic analysis. Twenty-four rats were randomized into a Scutellaria baicalensis group, a Scutellaria baicalensis+garlic group, a model control group and a normal control group with six rats in each group for detecting the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) with enzyme-linked immunosorbent assay (ELISA). The results showed that in the Scutellaria baicalensis group, the maximum concentration (C(max)) of baicalin, area under the plasma concentration-time curve (AUC) and the time to C(max) (T(max)) were significantly higher and apparent clearance (CL/F) were significantly lower than those of Scutellaria baicalensis+garlic group. The serum levels of TNF-alpha and IL-6 in the Scutellaria baicalensis group were both significantly lower than Scutellaria baicalensis+garlic group. It was then concluded that garlic not only had negative influence on the absorption of active compounds in Scutellaria baicalensis, but decreased the curative effects of Scutellaria baicalensis in treating model rats with pelvic inflammation. Garlic should not be co-administered with Scutellaria baicalensis.
该研究旨在探讨在盆腔炎模型大鼠治疗中，大蒜与黄芩共同给药是否对黄芩有负面影响。将12只模型大鼠随机分为黄芩组和黄芩+大蒜组，每组6只，进行药代动力学分析。将24只大鼠随机分为黄芩组、黄芩+大蒜组、模型对照组和正常对照组，每组6只，采用酶联免疫吸附测定法（ELISA）检测肿瘤坏死因子-α（TNF-α）和白细胞介素6（IL-6）的血清水平。结果显示，在黄芩组中，黄芩苷的最大浓度（C(max)）、血浆浓度-时间曲线下面积（AUC）以及达到C(max)的时间（T(max)）显著更高，表观清除率（CL/F）显著低于黄芩+大蒜组。黄芩组中TNF-α和IL-6的血清水平均显著低于黄芩+大蒜组。由此得出结论，大蒜不仅对黄芩中活性成分的吸收有负面影响，还降低了黄芩治疗盆腔炎模型大鼠的疗效。大蒜不应与黄芩共同给药。
