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Successful treatment of hypereosinophilic syndrome with cyclosporine.

作者信息

Donald Chancellor E, Kahn Marc J

机构信息

Section of Hematology and Medical Oncology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.

出版信息

Am J Med Sci. 2009 Jan;337(1):65-6. doi: 10.1097/MAJ.0b013e318169569a.

DOI:10.1097/MAJ.0b013e318169569a
PMID:19002011
Abstract

A 63-year-old man with lymphocytic variant hypereosinophilic syndrome (HES) characterized by a T-cell receptor gene rearrangement was treated with cyclosporine with marked improvement in his symptoms and reduction in his total eosinophil count. We present this as the first report to demonstrate cyclosporine as an effective treatment of HES in an adult.

摘要

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Treatment of hypereosinophilic syndrome in a child using cyclosporine: implication for a primary T-cell abnormality.使用环孢素治疗儿童嗜酸性粒细胞增多综合征:对原发性T细胞异常的启示
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Successful treatment of steroid resistant hypereosinophilic syndrome with low-dose CsA.小剂量环孢素成功治疗类固醇抵抗性高嗜酸性粒细胞综合征
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NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation.NIK 可防止小鼠发生类嗜酸性粒细胞增多综合征样疾病,而不依赖于 IKKα 的激活。
J Immunol. 2012 May 1;188(9):4602-10. doi: 10.4049/jimmunol.1200021. Epub 2012 Apr 2.