为什么许多精神疾病在青春期出现？
Why do many psychiatric disorders emerge during adolescence?
作者信息
Paus Tomás, Keshavan Matcheri, Giedd Jay N
机构信息
Brain & Body Centre, University of Nottingham, Nottingham, NG7 2RD, UK.
出版信息
Nat Rev Neurosci. 2008 Dec;9(12):947-57. doi: 10.1038/nrn2513. Epub 2008 Nov 12.
Abstract
The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable physical and behavioural changes. The processes in the brain that underlie these behavioural changes have been the subject of recent investigations. What do we know about the maturation of the human brain during adolescence? Do structural changes in the cerebral cortex reflect synaptic pruning? Are increases in white-matter volume driven by myelination? Is the adolescent brain more or less sensitive to reward? Finding answers to these questions might enable us to further our understanding of mental health during adolescence.
摘要
许多精神疾病的发病高峰年龄是青春期，这是一个身体和行为发生显著变化的时期。构成这些行为变化基础的大脑过程是最近研究的主题。我们对青春期人类大脑的成熟了解多少？大脑皮层的结构变化是否反映了突触修剪？白质体积的增加是由髓鞘形成驱动的吗？青春期大脑对奖励的敏感度是更高还是更低？找到这些问题的答案可能会使我们进一步了解青春期的心理健康。
相似文献
1
Why do many psychiatric disorders emerge during adolescence?为什么许多精神疾病在青春期出现？
Nat Rev Neurosci. 2008 Dec;9(12):947-57. doi: 10.1038/nrn2513. Epub 2008 Nov 12.
2
Brain structural and functional changes in adolescents with psychiatric disorders.患有精神疾病的青少年的大脑结构和功能变化。
Int J Adolesc Med Health. 2013;25(3):245-56. doi: 10.1515/ijamh-2013-0058.
3
Mapping brain maturation and cognitive development during adolescence.描绘青少年时期大脑的成熟过程与认知发展
Trends Cogn Sci. 2005 Feb;9(2):60-8. doi: 10.1016/j.tics.2004.12.008.
4
Alcohol, psychological dysregulation, and adolescent brain development.酒精、心理失调与青少年大脑发育
Alcohol Clin Exp Res. 2008 Mar;32(3):375-85. doi: 10.1111/j.1530-0277.2007.00601.x. Epub 2008 Jan 30.
5
GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies.γ-氨基丁酸能系统对青春期酒精反应性的影响：来自临床前和临床研究的见解
Pharmacol Ther. 2014 Aug;143(2):197-216. doi: 10.1016/j.pharmthera.2014.03.001. Epub 2014 Mar 11.
6
Cognitive and affective development in adolescence.青少年的认知与情感发展
Trends Cogn Sci. 2005 Feb;9(2):69-74. doi: 10.1016/j.tics.2004.12.005.
7
Sex differences in brain maturation during childhood and adolescence.儿童期和青春期大脑发育的性别差异。
Cereb Cortex. 2001 Jun;11(6):552-7. doi: 10.1093/cercor/11.6.552.
8
Sleep variability in adolescence is associated with altered brain development.青春期的睡眠变异性与大脑发育改变有关。
Dev Cogn Neurosci. 2015 Aug;14:16-22. doi: 10.1016/j.dcn.2015.05.007. Epub 2015 May 28.
9
Emergence of sex differences in the development of substance use and abuse during adolescence.青春期物质使用与滥用发展过程中性别差异的出现。
Pharmacol Ther. 2015 Sep;153:55-78. doi: 10.1016/j.pharmthera.2015.06.003. Epub 2015 Jun 3.
10
Reframing the Teenage Wasteland: Adolescent Microbiota-Gut-Brain Axis.重塑青少年荒原：青少年微生物群-肠-脑轴
Can J Psychiatry. 2016 Apr;61(4):214-21. doi: 10.1177/0706743716635536. Epub 2016 Feb 24.
引用本文的文献
1
Machine Learning in Adolescent Mental Health: Advanced Comorbidity Analysis and Text Mining Insights.青少年心理健康中的机器学习：高级共病分析与文本挖掘见解
Healthcare (Basel). 2025 Aug 29;13(17):2159. doi: 10.3390/healthcare13172159.
2
Weathering the storm: youth vulnerability and resilience during the climate crisis.经受风暴：气候危机期间的青年脆弱性与复原力
NPJ Clim Action. 2025;4(1):82. doi: 10.1038/s44168-025-00288-5. Epub 2025 Sep 6.
3
Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth.冲动性和神经质与青少年酒精使用风险具有不同的功能连接特征。
Mol Psychiatry. 2025 Sep 5. doi: 10.1038/s41380-025-03196-6.
4
Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the mouse frontal cortex.多巴胺能信号传导调节小鼠额叶皮质中的小胶质细胞监测和青少年可塑性。
Nat Commun. 2025 Aug 26;16(1):7974. doi: 10.1038/s41467-025-63314-4.
5
Scene construction deficits in adolescent PTSD are in sensory, rather than spatial, imagery.青少年创伤后应激障碍中的场景构建缺陷存在于感觉意象而非空间意象中。
Front Psychol. 2025 Aug 6;16:1589756. doi: 10.3389/fpsyg.2025.1589756. eCollection 2025.
6
Association Between 24-h Movement Behaviors and Mental Health in Children and Adolescents: A Systematic Review and Compositional Data Meta-Analysis.儿童和青少年24小时运动行为与心理健康之间的关联：一项系统评价与成分数据荟萃分析
Scand J Med Sci Sports. 2025 Aug;35(8):e70120. doi: 10.1111/sms.70120.
7
Mind the Gap: Does Brain Age Improve Alzheimer's Disease Prediction?注意差距：脑龄能否改善阿尔茨海默病的预测？
Hum Brain Mapp. 2025 Aug 15;46(12):e70276. doi: 10.1002/hbm.70276.
8
Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects.精神疾病在共同的通路上汇聚，但在细胞背景、空间分布和遗传效应的方向性上存在差异。
medRxiv. 2025 Jul 16:2025.07.11.25331381. doi: 10.1101/2025.07.11.25331381.
9
Precision functional mapping reveals less inter-individual variability in the child vs. adult human brain.精确功能图谱显示，儿童与成人大脑的个体间变异性较小。
bioRxiv. 2025 Jul 24:2025.07.21.665760. doi: 10.1101/2025.07.21.665760.
10
Distinct Neurodevelopmental Signatures of Sex-Specific Transcriptome-Based Polygenic Risk Scores for Depression.基于转录组的抑郁症性别特异性多基因风险评分的独特神经发育特征。
medRxiv. 2025 Jul 31:2025.07.31.25332511. doi: 10.1101/2025.07.31.25332511.
本文引用的文献
1
A self-report measure of pubertal status: Reliability, validity, and initial norms.一种青春期发育状况的自我报告测量方法：信度、效度和初步常模。
J Youth Adolesc. 1988 Apr;17(2):117-33. doi: 10.1007/BF01537962.
2
Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals.在“高危”个体发展为精神病的过程中，对渐进性脑结构变化进行了映射研究。
Schizophr Res. 2009 Mar;108(1-3):85-92. doi: 10.1016/j.schres.2008.11.026. Epub 2009 Jan 12.
3
Age differences in sensation seeking and impulsivity as indexed by behavior and self-report: evidence for a dual systems model.以行为和自我报告为指标的寻求刺激和冲动性方面的年龄差异：双系统模型的证据。
Dev Psychol. 2008 Nov;44(6):1764-78. doi: 10.1037/a0012955.
4
Growth of white matter in the adolescent brain: role of testosterone and androgen receptor.青少年大脑中白质的生长：睾酮和雄激素受体的作用
J Neurosci. 2008 Sep 17;28(38):9519-24. doi: 10.1523/JNEUROSCI.1212-08.2008.
5
A Social Neuroscience Perspective on Adolescent Risk-Taking.从社会神经科学视角看青少年冒险行为。
Dev Rev. 2008 Mar;28(1):78-106. doi: 10.1016/j.dr.2007.08.002.
6
Childhood and adolescent predictors of alcohol use and problems in adolescence and adulthood in the National Child Development Study.英国全国儿童发展研究中儿童期和青少年期酒精使用及青少年期和成年期问题的预测因素
Addiction. 2008 May;103 Suppl 1:7-22. doi: 10.1111/j.1360-0443.2008.02173.x.
7
The adolescent brain: insights from functional neuroimaging research.青少年大脑：来自功能神经影像研究的见解
Dev Neurobiol. 2008 May;68(6):729-43. doi: 10.1002/dneu.20615.
8
The descriptive epidemiology of commonly occurring mental disorders in the United States.美国常见精神障碍的描述性流行病学
Annu Rev Public Health. 2008;29:115-29. doi: 10.1146/annurev.publhealth.29.020907.090847.
9
Stress, sensitive periods and maturational events in adolescent depression.青少年抑郁症中的压力、敏感期和成熟事件。
Trends Neurosci. 2008 Apr;31(4):183-91. doi: 10.1016/j.tins.2008.01.004. Epub 2008 Mar 10.
10
Age differences in resistance to peer influence.同龄人影响抵抗力方面的年龄差异。
Dev Psychol. 2007 Nov;43(6):1531-1543. doi: 10.1037/0012-1649.43.6.1531.
Zotero 插件