Ernst Monique, Mueller Sven C
Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.
Dev Neurobiol. 2008 May;68(6):729-43. doi: 10.1002/dneu.20615.
With the development of functional neuroimaging tools, the past two decades have witnessed an explosion of work examining functional brain maps, mostly in the adult brain. Against this backdrop of work in adults, developmental research begins to gather a substantial body of knowledge about brain maturation. The purpose of this review is to present some of these findings from the perspective of functional neuroimaging. First, a brief survey of available neuroimaging techniques (i.e., fMRI, MRS, MEG, PET, SPECT, and infrared techniques) is provided. Next, the key cognitive, emotional, and social changes taking place during adolescence are outlined. The third section gives examples of how these behavioral changes can be understood from a neuroscience perspective. The conclusion places this functional neuroimaging research in relation to clinical and molecular work, and shows how answers will ultimately come from the combined efforts of these disciplines.
随着功能神经成像工具的发展,在过去二十年里,对功能脑图谱的研究呈爆发式增长,其中大部分研究针对的是成人大脑。在成人研究工作的这一背景下,发育研究开始积累大量关于大脑成熟的知识。本综述的目的是从功能神经成像的角度介绍其中的一些发现。首先,简要概述现有的神经成像技术(即功能磁共振成像、磁共振波谱、脑磁图、正电子发射断层扫描、单光子发射计算机断层扫描和红外技术)。接下来,概述青少年时期发生的关键认知、情感和社会变化。第三部分举例说明如何从神经科学角度理解这些行为变化。结论将这项功能神经成像研究与临床和分子研究联系起来,并展示最终如何通过这些学科的共同努力得出答案。