基于改良肾脏病膳食修正公式的 4 变量对卡铂剂量的评估。
Evaluation of carboplatin dosage based on 4-variable modification of diet in renal disease equation.
出版信息
Ir J Med Sci. 2009 Sep;178(3):301-7. doi: 10.1007/s11845-008-0250-z. Epub 2008 Nov 11.
BACKGROUND
Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR).
METHODS
We performed a retrospective analysis of carboplatin dosage in our institute. Calvert formula derived carboplatin dose using eGFR calculated from the MDRD equation was compared to estimated CrCl from the Cockcroft-Gault and Jelliffe equations.
RESULTS
Ninety-two carboplatin treatment episodes were recorded. eGFR and CrCl correlated reasonably well with a correlation coefficient (r) of 0.88. The correlation was weakest at lower levels of serum creatinine. Correcting eGFR for body surface area resulted in a tighter correlation (r = 0.94).
CONCLUSION
The MDRD derived eGFR is readily available and may prove very useful in calculating carboplatin dosage for patients with impaired renal function.
背景
传统上，卡铂剂量是基于卡尔弗特公式计算的。在该公式中，肾小球滤过率（GFR）和肌酐清除率（CrCl）经常互换使用。现在，肾脏病膳食改良（MDRD）方程通常可用于估计 GFR（eGFR）。
方法
我们对本院的卡铂剂量进行了回顾性分析。使用 MDRD 方程计算的 eGFR 推导的卡铂剂量与 Cockcroft-Gault 和 Jelliffe 方程估计的 CrCl 进行了比较。
结果
记录了 92 例卡铂治疗病例。eGFR 和 CrCl 相关性较好，相关系数（r）为 0.88。在血清肌酐水平较低时，相关性最弱。校正 eGFR 为体表面积后，相关性更强（r = 0.94）。
结论
MDRD 推导的 eGFR 易于获得，对于计算肾功能受损患者的卡铂剂量可能非常有用。
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