Sereno Maria, De Castro Javier, Belda-Iniesta Cristóbal, Garcia-Cabezas Miguel Angel, Cejas Paloma, Casado Enrique, Barriuso Jorge, Feliu Jaime, Larrauri Javier
Medical Oncology Division, Infanta Sofía Hospital, San Sebastian de los Reyes, Madrid, Spain.
Pathol Oncol Res. 2009 Mar;15(1):1-10. doi: 10.1007/s12253-008-9118-9. Epub 2008 Nov 11.
The primary aim was to determine whether Epo-R immunohistochemical expression is related to disease free survival (DFS) in specimens of GC from patients who underwent adjuvant chemoradiation. Specimens of gastric adenocarcinomas obtained from 44 patients who had undergone curative gastrectomy and adjuvant treatment were investigated immunohistochemically expression of Epo-R. Three patterns for Epo-R staining were defined: Pattern A (secretory cells-like staining), Pattern B (parietal-like staining) and Pattern C (chief-like staining). Median DFS was 38 months (CI 95%: 33-43) and 15 months (IC 95%: 3-27) in the pattern B and C, respectively, but it was not reached in the pattern A (p = 0.06). Our findings suggest that there may be a relationship between Epo-R expression and DFS in the patients with GC resected.
主要目的是确定在接受辅助放化疗的胃癌患者标本中，促红细胞生成素受体（Epo - R）的免疫组化表达是否与无病生存期（DFS）相关。对44例行根治性胃切除术并接受辅助治疗的胃腺癌患者的标本进行Epo - R免疫组化表达研究。定义了三种Epo - R染色模式：模式A（分泌细胞样染色）、模式B（壁细胞样染色）和模式C（主细胞样染色）。模式B和模式C的中位无病生存期分别为38个月（95%置信区间：33 - 43）和15个月（95%置信区间：3 - 27），而模式A未达到（p = 0.06）。我们的研究结果表明，在接受手术切除的胃癌患者中，Epo - R表达与无病生存期之间可能存在关联。
