雌激素受体与甲状腺癌恶性程度之间的关系。
Relation between estrogen receptor and malignancy of thyroid cancer.
作者信息
Takeichi N, Ito H, Haruta R, Matsuyama T, Dohi K, Tahara E
机构信息
Department of Surgery, Hiroshima University School of Medicine.
出版信息
Jpn J Cancer Res. 1991 Jan;82(1):19-22. doi: 10.1111/j.1349-7006.1991.tb01739.x.
The relationship between the histological grade of dedifferentiation of thyroid cancer and estrogen receptors (ER) was examined immunohistochemically. Thyroid cancers were from postmenopausal females of almost the same mean age (69-73 years old) and within the same period of time (1974-1983). ER immunoreactivity located in the nucleus of the epithelium was found in all 6 well differentiated papillary cancers, and 5 of them (83.3%) showed ER-immunoreactive (ER-IR) cells amounting to 20 or more per visual field (x 100) under a light microscope. Of the 6 cases of poorly differentiated papillary cancer, 5 (83.3%) had 1-19 ER-IR cells per visual field. ER-IR cells were negative in 5 out of 6 cases (83.3%) of anaplastic cancers. Thus, the number of ER-IR cells tended to decrease with the degree of atypism of thyroid cancer (P less than 0.001).
采用免疫组织化学方法研究了甲状腺癌去分化的组织学分级与雌激素受体（ER）之间的关系。甲状腺癌来自绝经后女性，平均年龄相近（69 - 73岁）且处于同一时间段（1974 - 1983年）。在所有6例高分化乳头状癌中均发现ER免疫反应性位于上皮细胞核内，其中5例（83.3%）在光学显微镜下每个视野（×100）显示ER免疫反应性（ER-IR）细胞达20个或更多。在6例低分化乳头状癌中，5例（83.3%）每个视野有1 - 19个ER-IR细胞。在6例未分化癌中有5例（83.3%）ER-IR细胞呈阴性。因此，ER-IR细胞数量倾向于随甲状腺癌异型程度的增加而减少（P < 0.001）。
Zotero 插件