Sakamoto A, Kasai N, Sugano H
Cancer. 1983 Nov 15;52(10):1849-55. doi: 10.1002/1097-0142(19831115)52:10<1849::aid-cncr2820521015>3.0.co;2-x.
The relationship between histologic type and survival of 258 thyroid malignancies has been analysed. A new clinicopathologic entity, poorly differentiated carcinoma of the thyroid, is proposed. Papillary and follicular carcinomas of the thyroid showed no significant difference in survival rates. Both tumors were histologically separated into well differentiated and poorly differentiated carcinomas, so that thyroid cancer, deriving from follicular cells, was divided into well differentiated, poorly differentiated, and anaplastic carcinomas. The characteristic histology of poorly differentiated carcinoma was the presence of solid, trabecular and/or scirrhous patterns. Poorly differentiated carcinoma was found in 13.6% of all thyroid malignancies, and its prognosis was worse than that of well differentiated carcinoma. The differences of survival rates among well differentiated, poorly differentiated and anaplastic carcinomas were statistically significant. Prognostic data support the suggestion that the clinicopathologic entity of poorly differentiated carcinoma is of value in determining management and survival of thyroid cancer patients.
分析了258例甲状腺恶性肿瘤的组织学类型与生存率之间的关系。提出了一种新的临床病理实体——甲状腺低分化癌。甲状腺乳头状癌和滤泡状癌的生存率无显著差异。这两种肿瘤在组织学上均分为高分化和低分化癌，因此起源于滤泡细胞的甲状腺癌分为高分化、低分化和未分化癌。低分化癌的特征性组织学表现为实性、小梁状和/或硬癌模式。低分化癌占所有甲状腺恶性肿瘤的13.6%，其预后比高分化癌差。高分化、低分化和未分化癌之间的生存率差异具有统计学意义。预后数据支持以下观点：低分化癌的临床病理实体在确定甲状腺癌患者的治疗和生存方面具有价值。
