Athanasopoulos Anastasios, Perimenis Petros
Department of Urology, Medical School, University of Patras, Rio, Patras, Greece.
Int Urogynecol J Pelvic Floor Dysfunct. 2009 Apr;20(4):475-82. doi: 10.1007/s00192-008-0761-1. Epub 2008 Nov 12.
The pathophysiology of urinary incontinence (UI) involves an overactive detrusor (DOA) or an incompetent urethral sphincter. Therefore, the three most common types of UI are stress urinary incontinence (SUI), urge urinary incontinence (UUI), or a combination of stress and urge known as mixed urinary incontinence (MUI). Pharmacotherapy represents a recognized option for the treatment of different types of UI. A literature search of Medline publications on pharmacological treatment of urinary incontinence until 2008 was performed. Relevant data from recently published literature were included. Anticholinergics are the cornerstone of UUI treatment, whereas serotonin and norepinephrine re-uptake inhibitors represent an option for SUI treatment. A significant percentage of patients with UI, mainly those with UUI and MUI, can be treated successfully with pharmacotherapy.
尿失禁（UI）的病理生理学涉及逼尿肌过度活跃（DOA）或尿道括约肌功能不全。因此，最常见的三种尿失禁类型是压力性尿失禁（SUI）、急迫性尿失禁（UUI）或压力性和急迫性混合的混合性尿失禁（MUI）。药物治疗是治疗不同类型尿失禁的一种公认选择。对截至2008年关于尿失禁药物治疗的Medline出版物进行了文献检索。纳入了最近发表文献中的相关数据。抗胆碱能药物是治疗UUI的基石，而5-羟色胺和去甲肾上腺素再摄取抑制剂是治疗SUI的一种选择。相当一部分尿失禁患者，主要是UUI和MUI患者，可以通过药物治疗成功治愈。
