肿瘤细胞的凋亡抵抗。
Apoptosis resistance in tumor cells.
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113, Japan.
出版信息
Cytotechnology. 1998 Sep;27(1-3):293-308. doi: 10.1023/A:1008058031511.
Abstract
Various antitumor agents induce apoptotic cell death in tumor cells. Since the apoptosis program in tumor cells plays a critical role in the chemotherapy-induced tumor cell killing, it is suggested that the defect in the signaling pathway of apoptosis could cause a new form of multidrug resistance in tumor cells. This article describes the recent findings concerning the mechanisms of chemotherapy-induced apoptosis and discusses the implication of apoptosis resistance in cancer chemotherapy.
摘要
各种抗肿瘤药物可诱导肿瘤细胞发生凋亡性细胞死亡。由于肿瘤细胞中的凋亡程序在化疗诱导的肿瘤细胞杀伤中起着关键作用，因此，凋亡信号通路的缺陷可能导致肿瘤细胞产生一种新的多药耐药形式。本文描述了关于化疗诱导细胞凋亡的机制的最新发现，并讨论了凋亡抵抗在癌症化疗中的意义。
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Death and the cell.死亡与细胞。
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Caspase activity is required for commitment to Fas-mediated apoptosis.半胱天冬酶活性是Fas介导的细胞凋亡所必需的。
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The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin.Jun激酶/应激激活蛋白激酶途径发挥调节DNA修复的功能，抑制该途径会使肿瘤细胞对顺铂敏感。
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Induction of apoptosis by the transcription factor c-Jun.转录因子c-Jun诱导细胞凋亡
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9
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.DFF是一种异二聚体蛋白，在细胞凋亡过程中，它在半胱天冬酶-3下游发挥作用，触发DNA片段化。
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10
c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation.c-Jun氨基末端激酶对小细胞肺癌细胞紫外线辐射凋亡反应的调控
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