肿瘤细胞的凋亡抵抗。
Apoptosis resistance in tumor cells.
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113, Japan.
出版信息
Cytotechnology. 1998 Sep;27(1-3):293-308. doi: 10.1023/A:1008058031511.
Abstract
Various antitumor agents induce apoptotic cell death in tumor cells. Since the apoptosis program in tumor cells plays a critical role in the chemotherapy-induced tumor cell killing, it is suggested that the defect in the signaling pathway of apoptosis could cause a new form of multidrug resistance in tumor cells. This article describes the recent findings concerning the mechanisms of chemotherapy-induced apoptosis and discusses the implication of apoptosis resistance in cancer chemotherapy.
摘要
各种抗肿瘤药物可诱导肿瘤细胞发生凋亡性细胞死亡。由于肿瘤细胞中的凋亡程序在化疗诱导的肿瘤细胞杀伤中起着关键作用，因此，凋亡信号通路的缺陷可能导致肿瘤细胞产生一种新的多药耐药形式。本文描述了关于化疗诱导细胞凋亡的机制的最新发现，并讨论了凋亡抵抗在癌症化疗中的意义。
相似文献
1
Apoptosis resistance in tumor cells.
Cytotechnology. 1998 Sep;27(1-3):293-308. doi: 10.1023/A:1008058031511.
2
A new challenge for successful immunotherapy by tumors that are resistant to apoptosis: two complementary signals to overcome cross-resistance.
Adv Cancer Res. 2002;85:145-74. doi: 10.1016/s0065-230x(02)85005-9.
3
[Cancer chemotherapy and apoptosis].
Nihon Rinsho. 1996 Jul;54(7):1935-42.
4
URGCP/URG4 promotes apoptotic resistance in bladder cancer cells by activating NF-κB signaling.
Oncotarget. 2015 Oct 13;6(31):30887-901. doi: 10.18632/oncotarget.5134.
5
Molecular cancer therapeutics: recent progress and targets in drug resistance.
Intern Med. 2003 Mar;42(3):237-43. doi: 10.2169/internalmedicine.42.237.
6
Apoptotic pathways in tumor progression and therapy.
Adv Exp Med Biol. 2008;615:47-79. doi: 10.1007/978-1-4020-6554-5_4.
7
Reversing Multidrug Resistance in Chemo-resistant Human Lung Adenocarcinoma (A549/DOX) Cells by Algerian Propolis Through Direct Inhibiting the P-gp Efflux-pump, G0/G1 Cell Cycle Arrest and Apoptosis Induction.
Anticancer Agents Med Chem. 2018;18(9):1330-1337. doi: 10.2174/1871520618666180808100800.
8
Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells.
PLoS One. 2007 Aug 1;2(8):e693. doi: 10.1371/journal.pone.0000693.
9
Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.
Leukemia. 2001 Jun;15(6):936-41. doi: 10.1038/sj.leu.2402127.
10
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Cancer Res. 2006 Sep 1;66(17):8520-8. doi: 10.1158/0008-5472.CAN-05-4364.
引用本文的文献
1
Eriodictyol mediated selective targeting of the TNFR1/FADD/TRADD axis in cancer cells induce apoptosis and inhibit tumor progression and metastasis.
Transl Oncol. 2022 Jul;21:101433. doi: 10.1016/j.tranon.2022.101433. Epub 2022 Apr 21.
2
PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension.
FASEB J. 2021 Aug;35(8):e21771. doi: 10.1096/fj.202100361R.
本文引用的文献
1
Death and the cell.
Immunol Today. 1986 Apr;7(4):115-9. doi: 10.1016/0167-5699(86)90152-0.
2
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis.
Nat Biotechnol. 1996 Mar;14(3):297-301. doi: 10.1038/nbt0396-297.
3
Caspase activity is required for commitment to Fas-mediated apoptosis.
EMBO J. 1997 Jul 1;16(13):3805-12. doi: 10.1093/emboj/16.13.3805.
4
Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
Cell. 1997 Jun 27;89(7):1067-76. doi: 10.1016/s0092-8674(00)80294-9.
5
Activation of the JNK pathway is essential for transformation by the Met oncogene.
EMBO J. 1997 May 15;16(10):2634-45. doi: 10.1093/emboj/16.10.2634.
6
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
Science. 1997 Jun 6;276(5318):1571-4. doi: 10.1126/science.276.5318.1571.
7
The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin.
J Biol Chem. 1997 May 30;272(22):14041-4. doi: 10.1074/jbc.272.22.14041.
8
Induction of apoptosis by the transcription factor c-Jun.
EMBO J. 1997 Apr 1;16(7):1695-709. doi: 10.1093/emboj/16.7.1695.
9
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.
Cell. 1997 Apr 18;89(2):175-84. doi: 10.1016/s0092-8674(00)80197-x.
10
c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation.
J Biol Chem. 1997 Apr 11;272(15):10110-6. doi: 10.1074/jbc.272.15.10110.
Zotero 插件