Dept. of Chemistry, Dept. of Applied Biology, University of Central Lancashire, Preston, Lancashire, PR1 2 HE, UK E-mail,
Cytotechnology. 1999 Jan;29(1):35-43. doi: 10.1023/A:1008098810928.
The triarylmethane dye Victoria blue BO (VBBO) is a known photosensitizer which has been shown to induce a cytotoxic response in vitro. Several novel Victoria blue derivatives, with varying physicochemical properties, have been compared to VBBO, with respect both to dark toxicity and phototoxicity, on a mouse mammary tumour cell line, EMT6. Photosensitizer uptake was observed using confocal fluorescence microscopy. The chemical differences, particularly in the naphthyl substitution of the derivatives were shown to alter the light:dark toxicity differential and the uptake of the photosensitizers.
三芳甲烷染料维多利亚蓝 BO（VBBO）是一种已知的光敏剂，已被证明可在体外诱导细胞毒性反应。几种新型维多利亚蓝衍生物，具有不同的物理化学性质，已在小鼠乳腺癌细胞系 EMT6 上与 VBBO 进行了比较，比较了暗毒性和光毒性。使用共聚焦荧光显微镜观察了光敏剂的摄取。化学差异，特别是衍生物中萘基的取代，被证明改变了光：暗毒性差异和光敏剂的摄取。
