Istituto di Cibernetica "E.Caianiello" del CNR, Via Campi Flegrei 34, 80078, Pozzuoli (NA), Italy,
Cogn Neurodyn. 2008 Dec;2(4):335-45. doi: 10.1007/s11571-008-9057-x. Epub 2008 Sep 19.
The investigation on the conditions which cause global population oscillatory activities in neural fields, originated some years ago with reference to a kinetic theory of neural systems, as been further deepened in this paper. In particular, the genesis of sharp waves and of some rhythmic activities, such as theta and gamma rhythms, of the hippocampal CA3 field, behaviorally important for their links to learning and memory, has been analyzed with more details. To this aim, the modeling-computational framework previously devised for the study of activities in large neural fields, has been enhanced in such a way that a greater number of biological features, extended dendritic trees-in particular, could be taken into account. By using that methodology, a two-dimensional model of the entire CA3 field has been described and its activity, as it results from the several external inputs impinging on it, has been simulated. As a consequence of these investigations, some hypotheses have been elaborated about the possible function of global oscillatory activities of neural populations of Hippocampus in the engram formation.
本文对神经场中引起全球人口波动活动的条件进行了深入研究。该研究最初源于对神经系统动力学理论的参考，特别是对海马 CA3 场中产生的尖波和一些节律性活动（如θ和γ节律）的起源进行了更详细的分析，这些活动在学习和记忆方面具有重要的联系。为此，我们以前用于研究大神经场活动的建模计算框架得到了增强，以便可以考虑更多的生物学特征，特别是扩展的树突。通过使用该方法，描述了整个 CA3 场的二维模型，并模拟了它的活动，因为它是由作用于其上的几个外部输入产生的。作为这些研究的结果，提出了一些关于海马体神经群体的全球波动活动在记忆形成中的可能功能的假设。
